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Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.

Authors
Shvedova-AA; Kapralov-AA; Feng-WH; Kisin-ER; Murray-AR; Mercer-RR; St. Croix-CM; Lang-MA; Watkins-SC; Konduru-NV; Allen-BL; Conroy-J; Kotchey-GP; Mohamed-BM; Mead-AD; Volkov-Y; Star-A; Fadeel-B; Kagan-VE
Source
PLoS One 2012 Mar; 7(3):e30923
NIOSHTIC No.
20040592
Abstract
Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and proinflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO - one of the key-orchestrators of inflammatory response - in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations.
Keywords
Pulmonary-system; Pulmonary-system-disorders; Pulmonary-function-tests; Pulmonary-function; Fibrosis; Oxidative-processes; Stress; Mesothelial-cells; Carcinogens; Laboratory-animals; Cell-biology; Cell-cultures; Cell-function; Animals; Animal-studies; Nanotechnology
CODEN
POLNCL
Publication Date
20120301
Document Type
Journal Article
Email Address
kagan@pitt.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282; B04132012
Issue of Publication
3
ISSN
1932-6203
NIOSH Division
HELD
Priority Area
Mining
Source Name
Public Library of Science One
State
PA; WV
Performing Organization
University of Pittsburgh at Pittsburgh
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