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Experimental human exposure to inhaled grain dust and ammonia: towards a model of concentrated animal feeding operations.

Authors
Sigurdarson-ST; O'Shaughnessy-PT; Watt-JA; Kline-JN
Source
Am J Ind Med 2004 Oct; 46(4):345-348
NIOSHTIC No.
20040546
Abstract
BACKGROUND: Ammonia and endotoxin-rich dust are present in high concentrations in swine confinement facilities; exposure to this environment is linked to workers' respiratory problems. We hypothesized that experimental exposure to ammonia and dust would impair pulmonary function, and that these exposures would be synergistic. METHODS: We exposed six normal subjects and eight subjects with mild asthma to ammonia (16-25 ppm) and/or endotoxin-rich grain dust (4 mg/m3). Pulmonary function and exhaled NOx were measured before and after exposure. RESULTS: There was no significant change in pulmonary function in the normal subjects following any of the exposure conditions. Among asthmatics, a significant transient decrease in FEV1 was induced by grain dust, but was not altered by ammonia; increased bronchial hyperreactivity was also noted in this group. CONCLUSION: In a vulnerable population, exposure to grain dust results in transient airflow obstruction. Short-term exposure to ammonia does not increase this response.
Keywords
Time-weighted-average-exposure; Respiration; Respiratory-irritants; Respiratory-system-disorders; Inhalants; Lung; Lung-disorders; Lung-function; Exposure-levels; Exposure-limits; Humans; Men; Women; Animals; Animal-husbandry; Age-groups; Poisons; Dusts; Diseases; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Grain-dusts; Author Keywords: asthma; airway inflammation; swine confinement; concentrated animal feeding operation
Contact
Joel N. Kline, C33GH UIHC, 200 Newton Road, Iowa City, IA 52242
CODEN
AJIMD8
CAS No.
7664-41-7
Publication Date
20041001
Document Type
Journal Article
Email Address
oel-kline@uiowa.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008491
Issue of Publication
4
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
IA
Performing Organization
University of Iowa
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