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Irritancy and allergic responses induced by exposure to the indoor air chemical 4-oxopentanal.

Authors
Anderson-SE; Franko-J; Jackson-LG; Wells-JR; Ham-JE; Meade-BJ
Source
Toxicol Sci 2012 Jun; 127(2):371-381
NIOSHTIC No.
20040512
Abstract
Over the last two decades, there has been an increasing awareness regarding the potential impact of indoor air pollution on human health. People working in an indoor environment often experience symptoms such as eye, nose and throat irritation. Investigations into these complaints have ascribed the effects, in part, to compounds emitted from building materials, cleaning/consumer products, and indoor chemistry. One suspect indoor air contaminant that has been identified is the dicarbonyl 4- oxopentanal (4-OPA). 4-OPA is generated through the ozonolysis of squalene and several high volume production compounds that are commonly found indoors. Following preliminary workplace sampling that identified the presence of 4-OPA, these studies examined the inflamatory and allergic responses to 4-OPA following both dermal and pulmonary exposure using a murine model. 4-OPA was tested in a combined local lymph node assay (LLNA) and identified to be an irritant and sensitizer. A Th1-mediated hypersensitivity response was supported by a positive response in the mouse ear swelling test (MEST). Pulmonary exposure to 4-OPA caused a significant elevation in nonspecific airway hyperreactivity, increased numbers of lung associated lymphocytes and neutrophils and increased interferon-g production by lung associated lymph nodes. These results suggest that both dermal and pulmonary exposure to 4-OPA may elicit irritant and allergic responses and may help to explain some of the adverse health effects associated with poor indoor air quality.
Keywords
Indoor-air-pollution; Indoor-environmental-quality; Humans; Men; Women; Workers; Work-environment; Physical-reactions; Irritants; Eye-irritants; Emission-sources; Air-contamination; Skin-exposure; Pulmonary-function; Pulmonary-system; Respiratory-irritants; Respiratory-system-disorders; Hypersensitivity; Lung-irritants; Lung-cells; Lung-tissue; Lymph-nodes; Author Keywords: Dicarbonyls; Oxygenated Reaction Products; Hypersensitivity; LLNA; Indoor Air
Contact
Stacey E. Anderson, Ph.D, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505
CODEN
TOSCF2
CAS No.
626-96-0
Publication Date
20120601
Document Type
Journal Article
Email Address
sanderson4@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B03282012
Issue of Publication
2
ISSN
1096-6080
NIOSH Division
HELD
Source Name
Toxicological Sciences
State
WV
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