Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Letter to the editor re: Multiple sclerosis (MS) in an Illinois community (Arch Environ Health. 2001 Sep-Oct;56(5):389-95).

Authors
Park-RM; Boal-WL; Krebs-JM
Source
Arch Environ Health 2002 Jul/Aug; 57(4):383
NIOSHTIC No.
20040509
Abstract
In their study of multiple sclerosis (MS) in an Illinois community, Schiffer et al.' focused on exposures from a zinc smelter, in further support of a zinc hypothesis previously proposed by Stein et al, and based on an MS cluster at a zinc die-casting plant in New York State. A subsequent study at the New York plant, which we performed and published in 1995 (Schiffer et al. did not cite this study), assessed other exposures in addition to zinc that could possibly be associated with neurological disorders that produced MS-like syrnptoms. We identified a class of synthetic oils-triaryl phosphate esters-that were used widely in the plant as fire-resistant hydraulic fluids; these could plausibly have played a role. Our analysis showed an association between the onset of MS-like disease in work areas where these chemicals were used and where die-casting occurred (correlated exposures). The neurotoxicological properties of some of these organophosphates are well known. For example, the substance tri-ortho-cresyl phosphate causes a delayed dying-back axonopathy. Exposures to these materials, present as crude mixtures of aryl phosphate esters, were proposed as an alternative plausible agent in the MS cluster. We suggest that, like the zinc hypothesis, the triaryl phosphate ester hypothesis deserves testing for industrial clusters of what appears to be MS. We wonder if organic compounds present at the contaminated Illinois site were identified in the exposure assessment conducted there. It would be especially noteworthy if any MS cases occurred among employees of the smelter, and if phosphate esters were used there, inasmuch as fire-resistant hydraulic fluids and lubricants are commonly used in high-temperature applications.
Keywords
Exposure-levels; Exposure-limits; Nerve-damage; Nerve-function; Nerve-tissue; Nerves; Nervous-system-disorders; Nervous-system-function; Zinc-compounds; Hydraulic-fluids; Work-areas; Neurotoxic-effects
CODEN
AEHLAU
CAS No.
7440-66-6
Publication Date
20020701
Document Type
Other
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0003-9896
NIOSH Division
EID; DSHEFS
Source Name
Archives of Environmental Health
State
OH; MI; TX
TOP