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Determination of the extravascular burden of carbon monoxide (CO) on human heart.

Authors
Erupaka-K
Source
Lexington, Kentucky: University of Kentucky, 2008, Jan; :1-148
NIOSHTIC No.
20040440
Abstract
Noninvasive measurements of myocardial carboxymyoglobin levels (%MbCO) and oxygen tensions (PtO2) are difficult to obtain experimentally. We have developed a compartmental model which allows prediction of myocardial %MbCO levels and PtO2 for varied carbon monoxide (CO) exposures. The cardiac compartment in the model consists of vascular subcompartments which contain two tissue subcompartments varying in capillary density. Mass-balance equations for oxygen (O2) and CO are applied for all compartments. Myocardial oxygen consumption and blood flow are quantified from predictive formulas based on heart rate. Model predictions are validated with experimental data at normoxia, hypoxia, exercise and hyperoxia. CO exposures of varying concentration and time (short-high, long-low), CO rebreathing during 100% O2, and exposure during exercise is simulated. Results of the simulations demonstrate that during CO exposures and subsequent therapies, the temporal changes of %MbCO in the heart differ from those of carboxyhemoglobin levels (%HbCO). Analysis of correlation between %HbCO, %MbCO and PtO2 was done to understand myocardial injury due to CO hypoxia. This thesis demonstrates that the model is able to anticipate the uptake and distribution of CO in the human myocardium and thus can be used to estimate the extravascular burden (MbCO, PtO2 ) of CO on the human heart.
Keywords
Carbonyls; Poison-gases; Poisons; Cardiac-function; Cardiopulmonary-system-disorders; Cardiovascular-system-disease; Heart; Heart-rate; Exposure-levels; Exposure-limits; Hypoxia; Physical-exercise; Author Keywords: Myocardial Oxygen Tension; CO Hypoxia; Exercise; Tissue Oxygenation; Cardiac Muscle
CAS No.
630-08-0
Publication Date
20080109
Document Type
Dissertation
Email Address
kinnerarey@uky.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008651
Source Name
Determination of the extravascular burden of carbon monoxide (CO) on human heart
State
KY
Performing Organization
University of Kentucky
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