Hematological Effects of Long-Term Radiation Exposure in Russian Nuclear Workers. Soaita AL, Day RD, Azizova T, eds. Saarbrücken, Germany: VDM Verlag Dr. Mueller, 2008 Jan; :1-212
This book covers the following: INTRODUCTION, GENERAL FRAMEWORK, LITERATURE REVIEW: radiation dose-response models, radiation effects at chromosomal and cellular level, radiosensitivity of the hematopoietic system, mayak product association, previous studies of long term occupational radiation exposure, sex related differences in radiosensitivity; Review of Repeated Measures Analysis Techniques: univariate analysis of variance (ANOVA), generalized linear models (GLM), linear mixed models, marginal model and GEE (generalized estimating equations), spline function, missing data, methodological overview - summary. OBJECTIVES AND SPECIFIC AIMS, METHODOLOGY, BACKGROUND, MAYAK PA WORKERS' EARLY CLINICAL EFFECT DATABASE: sampling procedures for MWECE database implementation, MWECE database format, study cohort. STUDY DESIGN: definition of study variables, descriptive analysis, statistical methods, missing data. RESULTS, DESCRIPTIVE ANALYSIS RESULTS: study cohort structure. MISSING DATA ASSESSMENT RESULTS: background, descriptive analysis of the missing data patterns, Missing Data Patterns and Mechanisms Assessment: drop-outs description, drop-outs mechanism assessment, mixed patterns missing data description, mixed patterns missing data assessment, Missing data analysis conclusion. STATISTICAL MODELING RESULTS: assessment of the coefficients in the models, assessment of goodness of fit of the models, numerical assessment of goodness of fit of the models, predicting the lymphocyte counts using the five models. DISCUSSION, STRENGTHS OF THE ANALYSIS, LIMITATION OFTHE ANALYSIS, CONCLUSIONS, PUBLIC HEALTH SIGNIFICANCE, APPENDIX A - RADIATION PHYSICS, APPENDIX B - MWECE DATABASE FORMAT, APPENDIX C MISSING DATA ASSESSMENT (STATA OUTPUT), APPENDIX D - LYMPHOCYTE COUNTS RANGE IN HUMANS, and BIBLIOGRAPHY.
Radiation; Radiation-effects; Radiation-monitoring; Dosimetry; Injuries; Biological-effects; Nuclear-radiation; Nuclear-hazards; Employee-exposure; Ionizing-radiation; Acute-exposure; Acute-radiation-syndrome; Accidents; Dose-response; Clinical-diagnosis; Clinical-symptoms; Clinical-tests; Hematology; Hemodynamics; Blood-analysis; Blood-cells; Blood-disorders; Surveillance-programs; Information-retrieval-systems; Information-systems; Sex-factors; Mathematical-models; Chromosome-damage; Cell-damage; Cellular-function; Statistical-analysis; Exposure-assessment; Lymphocytes; Long-term-study; Sampling
Tamara V. Azizova, Southern Urals Biophysics Institute, 19 Ozyorskoe shosse, Ozyorsk, Chelyabinsk region, 456780, Russia