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Association between cleaning-related chemicals and work-related asthma and asthma symptoms among healthcare professionals.

Authors
Arif-AA; Delclos-GL
Source
Occup Environ Med 2012 Jan; 69(1):35-40
NIOSHTIC No.
20040294
Abstract
OBJECTIVES: Work-related asthma (WRA) is an important public health problem affecting one quarter of adults with asthma. Although cleaning substances are routinely used in hospitals, few studies have addressed their potential adverse respiratory health effects on healthcare professionals (HCPs). This study attempts to identify relationship between work-related exposure to cleaning-related chemicals and development of WRA among HCPs. METHODS: Of 5600 HCPs surveyed, 3650 responded to a validated questionnaire about their occupation, asthma diagnosis, variability of asthma symptoms at and away from work, and exposure to individual cleaning substances. Workplace asthma was defined as a categorical variable with four mutually exclusive categories: work-related asthma symptoms (WRAS), work-exacerbated asthma (WEA), occupational asthma (OA) and none. Multivariable logistic regression analysis was used to evaluate the association between self-reported use of cleaning substances and asthma outcomes among HCPs. RESULTS: Prevalences of WRAS, WEA and OA were 3.3%, 1.1% and 0.8%, respectively. The prevalence estimates were generally higher among female than male HCPs. The odds of WRAS and WEA increased in a dose-dependent manner for exposure in the longest job to cleaning agents and disinfectants/sterilants, respectively. For exposure in any job, the odds of WRAS were significantly elevated for both factor 1 (bleach, cleaners/abrasives, toilet cleaners, detergents and ammonia) and factor 2 (glutaraldehyde/ortho-phtaldehyde, chloramines and ethylene oxide). Significantly elevated odds of WEA were observed for exposure to bleach, factor 2 and formalin/formaldehyde. Exposure to chloramines was significantly associated with an almost fivefold elevated odds of OA. CONCLUSIONS: HCPs are at risk of developing WRA from exposure to cleaning substances.
Keywords
Respiratory-system-disorders; Respiratory-irritants; Respiratory-infections; Respiration; Pulmonary-system-disorders; Pulmonary-system; Pulmonary-function; Pulmonary-disorders; Breathing; Housekeeping-products; Health-care-personnel; Health-care-facilities; Health-care; Medical-facilities; Medical-personnel; Questionnaires; Humans; Men; Women; Detergents; Epidemiology; Statistical-analysis
Contact
Ahmed A Arif, Associate Professor, UNC Charlotte, Department of Public Health Sciences, CHHS 429, 9201 University City Blvd, Charlotte, NC 28223
CODEN
OEMEEM
Publication Date
20120101
Document Type
Journal Article
Email Address
aarif@uncc.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003945; Grant-Number-T42-CCT-610417; B02172012
Issue of Publication
1
ISSN
1351-0711
Source Name
Occupational and Environmental Medicine
State
NC; TX
Performing Organization
University of Texas, Health Science Center, Houston
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