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Lung pathologic findings in a local residential and working community exposed to World Trade Center dust, gas, and fumes.

Authors
Caplan-Shaw-CE; Yee-H; Rogers-L; Abraham-JL; Parsia-SS; Naidich-DP; Borczuk-A; Moreira-A; Shiau-MC; Ko-JP; Brusca-Augello-G; Berger-KI; Goldring-RM; Reibman-J
Source
J Occup Environ Med 2011 Sep; 53(9):981-991
NIOSHTIC No.
20040288
Abstract
OBJECTIVE: To describe pathologic findings in symptomatic World Trade Center-exposed local workers, residents, and cleanup workers enrolled in a treatment program. METHODS: Twelve patients underwent surgical lung biopsy for suspected interstitial lung disease (group 1, n = 6) or abnormal pulmonary function tests (group 2, n = 6). High-resolution computed axial tomography and pathologic findings were coded. Scanning electron microscopy with energy-dispersive x-ray spectroscopy was performed. RESULTS: High-resolution computed axial tomography showed reticular findings (group 1) or normal or airway-related findings (group 2). Pulmonary function tests were predominantly restrictive. Interstitial fibrosis, emphysematous change, and small airway abnormalities were seen. All cases had opaque and birefringent particles within macrophages, and examined particles contained silica, aluminum silicates, titanium dioxide, talc, and metals. CONCLUSIONS: In symptomatic World Trade Center-exposed individuals, pathologic findings suggest a common exposure resulting in alveolar loss and a diverse response to injury.
Keywords
Pathology; Pathogens; Exposure-levels; Exposure-limits; Dusts; Dust-particles; Dust-inhalation; Dust-explosions; Lung-disease; Lung; Lung-disorders; Lung-function; Pulmonary-function; Pulmonary-system-disorders; Pulmonary-system; Respiratory-system-disorders; Fibrous-dusts; Particulate-dust; Particulates; Silica-dusts; Talc; Talc-dust; Metal-dusts; Metallic-dusts; Humans; Men; Women; Environmental-exposure; Age-groups; Gases; Air-contamination; Airborne-dusts; Airborne-fibers; Airborne-particles
Contact
Joan Reibman, MD, New York University School of Medicine, 550 1st Ave, Room NB-7N24, New York, NY 10016
CODEN
JOEMFM
Publication Date
20110901
Document Type
Journal Article
Email Address
joan.reibman@nyumc.org
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-E11-OH-009630
Issue of Publication
9
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
NY
Performing Organization
New York City Health and Hospitals Corporation
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