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Pathogenesis and disease mechanisms of occupational asthma.

Authors
Lummus-ZL; Wisnewski-AV; Bernstein-DI
Source
Immunol Allergy Clin North Am 2011 Nov; 31(4):699-716
NIOSHTIC No.
20040251
Abstract
Occupational asthma (OA) is one of the most common forms of work-related lung disease in all industrialized nations. The clinical management of patients with OA depends on an understanding of the multifactorial pathogenetic mechanisms that can contribute to this disease. This article discusses the various immunologic and nonimmunologic mechanisms and genetic susceptibility factors that drive the inflammatory processes of OA.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Bronchial-asthma; Pathology; Pathogenesis; Immune-reaction; Immunology; Genetic-factors; Genetics; Author Keywords: Occupational asthma; Airway hyperresponsiveness; Workplace allergens; Immune mechanisms; Airway remodeling; Oxidative stress; Genetic susceptibility
Contact
David I. Bernstein, MD, Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, 3255 Eden Avenue, Cincinnati, OH 45267-0563, USA
Publication Date
20111101
Document Type
Journal Article
Email Address
Bernstdd@ucmail.uc.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008795
Issue of Publication
4
ISSN
0889-8561
Source Name
Immunology and Allergy Clinics of North America
State
OH; CT
Performing Organization
University of Cincinnati
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