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Sensitization and chronic beryllium disease at a primary manufacturing facility, part 1: historical exposure reconstruction.

Authors
Virji-MA; Park-JY; Stefaniak-AB; Stanton-ML; Day-GA; Kent-MS; Kreiss-K; Schuler-CR
Source
Scand J Work, Environ & Health 2012 Jun; 38(3):247-258
NIOSHTIC No.
20040247
Abstract
OBJECTIVES: Previous epidemiologic studies of beryllium sensitization (BeS) and chronic beryllium disease (CBD) have reported inconsistent exposure-response relationships, likely due to exposure misclassification. The objective of this study was to develop historical estimates of size-selective personal exposure to beryllium for an epidemiologic study. METHODS: In 1999, a cross-sectional survey of workers hired after 1 January 1994 was conducted at a beryllium production facility. Personal exposure data from two air sampling surveys conducted in 1999 were used to obtain total, respirable, and submicron particle baseline exposure estimates (BEE) for a job-exposure matrix (JEM). General area air samples collected from 1994-1999 were used to estimate annual changes in exposures (temporal factors) for 24 different process areas. Historical exposure estimates (HEE) were calculated by applying the temporal factors to the BEE. Workers were assigned HEE based on their work history, and their historical exposure profile was summarized as cumulative, average, or highest-ever job exposure. RESULTS: Changes in exposure over a 6-year period were observed in 10 of the 24 process areas with an overall mean decline of 18% per year. The overall total exposure for study participants over their work tenure ranged from: 0.001-34.44 g/m (3)-year, 0.01-16.26 g/m (3), and 0.01-17.54 g /m (3)for cumulative, average, and highest-ever job, respectively. For respirable exposures, the ranges were: 0.001-15.54 g/m (3)-year, 0.01-3.56 g/m (3), 0.01-5.54 g /m (3)for cumulative, average, and highest-ever job, respectively. CONCLUSIONS: Using this JEM, exposure-response relationships for BeS and CBD can be explored over a range of exposure metrics such as total, respirable, and submicron beryllium mass concentrations, including summary measures such as cumulative, average, or highest exposures, with the ultimate objective of elucidating a quantitative exposure-response relationship.
Keywords
Beryllium-disease; Beryllium-compounds; Beryllium-poisoning; Exposure-levels; Nanotechnology; Exposure-assessment; Author Keywords: average exposure; beryllium; chronic beryllium disease; cumulative exposure; exposure; exposure reconstruction; historical exposure; historical exposure reconstruction; manufacturing; peak exposure; respirable exposure; sensitization; submicron exposure; total exposure
Contact
M Abbas Virji, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H-2800, Morgantown, WV 26505.
CODEN
SWEHDO
Publication Date
20120601
Document Type
Journal Article
Email Address
MVirji@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0355-3140
NIOSH Division
DRDS
Source Name
Scandinavian Journal of Work, Environment and Health
State
WV
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