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An updated algorithm for estimation of pesticide exposure intensity in the Agricultural Health Study.

Authors
Coble-J; Thomas-KW; Hines-CJ; Hoppin-JA; Dosemeci-M; Curwin-B; Lubin-JH; Freeman-LEB; Blair-A; Sandler-DP; Alavanja-MCR
Source
Int J Environ Res Public Health 2011 Dec; 8(12):4608-4622
NIOSHTIC No.
20040207
Abstract
An algorithm developed to estimate pesticide exposure intensity for use in epidemiologic analyses was revised based on data from two exposure monitoring studies. In the first study, we estimated relative exposure intensity based on the results of measurements taken during the application of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) (n = 88) and the insecticide chlorpyrifos (n = 17). Modifications to the algorithm weighting factors were based on geometric means (GM) of post-application urine concentrations for applicators grouped by application method and use of chemically-resistant (CR) gloves. Measurement data from a second study were also used to evaluate relative exposure levels associated with air blast as compared to hand spray application methods. Algorithm modifications included an increase in the exposure reduction factor for use of CR gloves from 40% to 60%, an increase in the application method weight for boom spray relative to in-furrow and for air blast relative to hand spray, and a decrease in the weight for mixing relative to the new weights assigned for application methods. The weighting factors for the revised algorithm now incorporate exposure measurements taken on Agricultural Health Study (AHS) participants for the application methods and personal protective equipment (PPE) commonly reported by study participants.
Keywords
Agglutination; Agricultural-workers; Agricultural-chemicals; Pesticides; Insecticides; Pesticides-and-agricultural-chemicals; Exposure-assessment; Mathematical-models; Worker-health; Employee-exposure; Sprays; Gloves; Spraying-equipment; Epidemiology; Medical-monitoring; Surveillance-programs; Personal-protective-equipment; Author Keywords: pesticides; exposure algorithm; epidemiology; 2,4-D; chlorpyrifos; captan
Contact
Alavanja, MCR (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, DHHS, 1620 Execut Blvd, Rockville, MD 20892 USA
CODEN
IJERGQ
CAS No.
94-75-7; 2921-88-2; 133-06-2
Publication Date
20111201
Document Type
Journal Article
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
1660-4601
NIOSH Division
DSHEFS
Priority Area
Agriculture, Forestry and Fishing
Source Name
International Journal of Environmental Research and Public Health
State
MD; NC; OH
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