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A pilot case-cohort study of liver and pancreatic cancers in poultry workers.

Authors
Felini-M; Johnson-E; Preacely-N; Sarda-V; Ndetan-H; Bangara-S
Source
Ann Epidemiol 2011 Oct; 21(10):755-766
NIOSHTIC No.
20040140
Abstract
PURPOSE: To test the hypothesis that exposure to poultry oncogenic viruses that widely occurs occupationally in poultry workers and in the general population, may be associated with increased risks of deaths from liver and pancreatic cancers, and to identify new risk factors. METHODS: A pilot case-cohort study of both cancers within a combined cohort of 30,411 highly exposed poultry workers and 16,408 control subjects was conducted, and risk assessed by logistic regression odds ratios (OR) and proportional hazards risk ratios. RESULTS: New occupational findings were recorded respectively for pancreatic/liver cancers, for slaughtering of poultry (OR = 8.9, 95% confidence interval [CI]: 2.7-29.3)/OR = 9.1, 95% CI: 1.9-42.9); catching of live chickens (OR = 3.6, 95% CI: 1.2-10.9)/OR = 1.0, 95% CI: 0.1-8.5); killing other types of animals for food (OR = 4.8, 95% CI: 1.5-16.6)/OR = 2.0, 95% CI: 0.2-18.2), and ever worked on a pig raising farm (OR = 3.0, 95% CI: 1.0-8.2) for pancreatic cancer only. New non-occupational findings for liver cancer were for receiving immunization with yellow fever vaccine (OR = 8.7, 95% CI: 1.0-76.3); and vaccination with typhoid vaccine (OR = 6.3, 95% CI: 1.1-37.4). The study also confirmed previously reported risk factors for both diseases. CONCLUSIONS: This study provides preliminary evidence that exposure to poultry oncogenic viruses may possibly be associated with the occurrence of liver and pancreatic cancers. Case-control studies nested within occupational cohorts of highly exposed subjects of sufficient statistical power may provide an efficient and valid method of investigating/confirming these findings.
Keywords
Agriculture; Agricultural-workers; Animal-husbandry; Animal-husbandry-workers; Poultry-industry; Poultry; Poultry-workers; Cancer; Cancer-rates; Oncogenic-agents; Mortality-data; Mortality-rates; Liver-damage; Liver-disorders; Risk-analysis; Risk-factors; Statistical-analysis; Case-studies; Slaughterhouses; Vaccines; Viral-infections; Epidemiology; Author Keywords: Oncogenic Viruses; Pancreas; Poultry; Occupation; Liver; Cancer; Risk Factors
Contact
Dr. Eric S. Johnson, PhD, Department of Epidemiology, School of Public Health, UNT Health Sciences Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107
CODEN
ANNPE3
Publication Date
20111001
Document Type
Journal Article
Email Address
Eric.Johnson@unthsc.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008071; B01182012
Issue of Publication
10
ISSN
1047-2797
Source Name
Annals of Epidemiology
State
TX
Performing Organization
University of North Texas
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