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Overview of AHR functional domains and the classical AHR signaling pathway: induction of drug-metabolizing enzymes.

Authors
Ma-Q
Source
The AH Receptor in Biology and Toxicology. Pohjanvirta R, ed., Hoboken, NJ: Wiley, 2011 Dec; :33-45
NIOSHTIC No.
20040117
Abstract
This chapter contains sections titled: Introduction; Induction of CYP1A1 and the AHR Battery of DMES; Defining Major Components of CYP1A1 Induction; Molecular Characterization of AHR and ARNT; Other Components of Induction; The Classical Signaling Pathway of Gene Induction by AHR; Expanding Role of the AHR/ARNT/DRE Paradigm in AHR Biology; and, Conclusions
Keywords
Metabolic-activation; Metabolism; Genes; Genetics; Author Keywords: AHR; ligand-activated factor; AHR domains; signaling pathway; CYP1A1 induction; drug metabolizing
Publication Date
20111201
Document Type
Book or book chapter
Editors
Pohjanvirta-R
Fiscal Year
2012
NTIS Accession No.
NTIS Price
ISBN No.
9780470601822
Identifying No.
B01182012
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
The AH Receptor in Biology and Toxicology
State
WV
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