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In utero exposure to bisphenol-A and anogenital distance of male offspring.

Authors
Miao-M; Yuan-W; He-Y; Zhou-Z; Wang-J; Gao-E; Li-G; Li-D-K
Source
Birth Defects Res A Clin Mol Teratol 2011 Oct; 91(10):867-872
NIOSHTIC No.
20040105
Abstract
BACKGROUND: Bisphenol-A (BPA) is an endocrine disruptor with widespread human exposure. The effect of in utero BPA exposure on human offspring remains largely unknown. METHODS: Anogenital distance (AGD) of sons of workers who did or did not have occupational BPA exposure during pregnancy were compared in an occupational cohort study. Parental BPA exposure level during the index pregnancy was estimated through a job-exposure matrix based on personal air sampling measurement. Maternal exposure was considered direct in utero exposure to the fetus, whereas paternal exposure was considered indirect in utero exposure. RESULTS: A total of 153 boys were included in the final analysis, among them 56 with parental occupational exposure during pregnancy and 97 without. After controlling for the boys' ages and weights using linear regression, parental occupational exposure to BPA during pregnancy was associated with shortened AGD in male offspring. The association was stronger for maternal exposure (p < 0.01). There was also a dose-response relationship with increased BPA exposure levels in pregnancy associated with greater magnitude of shortened AGD in male offspring, with a statistically significant trend for the association (p = 0.008). CONCLUSION: Our findings provide the first epidemiologic evidence that in utero BPA exposure may adversely affect male genital development.
Keywords
Birth-defects; Reproductive-effects; Phenols; Endocrine-function; Endocrine-system; Exposure-assessment; In-utero-exposure; In-utero-study; Pregnancy; Prenatal-exposure; Reproductive-hazards; Reproductive-system; Pathology; Halides; Humans; Men; Women; Children; Epidemiology; Dose-response; Author Keywords: bisphenol-A; anogenital distance; in utero exposure; occupational exposure; endocrine disruptor
Contact
De-Kun Li, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612
CODEN
BDRPBT
CAS No.
80-05-7
Publication Date
20111001
Document Type
Journal Article
Email Address
dkl@dor.kaiser.org
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007580; B01182012
Issue of Publication
10
ISSN
1542-0752
Source Name
Birth Defects Research Part A: Clinical and Molecular Teratology
State
CA
Performing Organization
Kaiser Foundation Research Institute
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