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Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water.

Authors
Cragin-LA; Kesner-JS; Bachand-AM; Barr-DB; Meadows-JW; Krieg-EF; Reif-JS
Source
Environ Res 2011 Nov; 111(8):1293-1301
NIOSHTIC No.
20040029
Abstract
Atrazine is the most commonly used herbicide in the U.S. and a wide-spread groundwater contaminant. Epidemiologic and laboratory evidence exists that atrazine disrupts reproductive health and hormone secretion. We examined the relationship between exposure to atrazine in drinking water and menstrual cycle function including reproductive hormone levels. Women 18-40 years old residing in agricultural communities where atrazine is used extensively (Illinois) and sparingly (Vermont) answered a questionnaire (n=102), maintained menstrual cycle diaries (n=67), and provided daily urine samples for analyses of luteinizing hormone (LH), and estradiol and progesterone metabolites (n=35). Markers of exposures included state of residence, atrazine and chlorotriazine concentrations in tap water, municipal water and urine, and estimated dose from water consumption. Women who lived in Illinois were more likely to report menstrual cycle length irregularity (odds ratio (OR)=4.69; 95% confidence interval (CI): 1.58-13.95) and more than 6 weeks between periods (OR=6.16; 95% CI: 1.29-29.38) than those who lived in Vermont. Consumption of >2 cups of unfiltered Illinois water daily was associated with increased risk of irregular periods (OR=5.73; 95% CI: 1.58-20.77). Estimated "dose" of atrazine and chlorotriazine from tap water was inversely related to mean mid-luteal estradiol metabolite. Atrazine "dose" from municipal concentrations was directly related to follicular phase length and inversely related to mean mid-luteal progesterone metabolite levels. We present preliminary evidence that atrazine exposure, at levels below the US EPA MCL, is associated with increased menstrual cycle irregularity, longer follicular phases, and decreased levels of menstrual cycle endocrine biomarkers of infertile ovulatory cycles.
Keywords
Pest-control; Pesticides-and-agricultural-chemicals; Pesticide-residues; Dose-response; Epidemiology; Biological-monitoring; Biological-systems; Biological-effects; Occupational-exposure; Organo-phosphorus-pesticides; Environmental-exposure; Environmental-hazards; Environmental-contamination; Hepatotoxicity; Reproductive-hazards; Reproductive-system-disorders; Reproductive-effects; Women; Drinking-water; Menstrual-disorders; Hormone-activity; Agricultural-chemicals; Age-groups; Questionnaires; Author Keywords: Atrazine; Drinking water; Menstrual cycle; Hormones; Pesticide
Contact
Lori A. Cragin, Vermont Department of Health,108 Cherry St, Burlington, VT 05402, USA
CODEN
ENVRAL
CAS No.
1912-24-9; 108-77-0
Publication Date
20111101
Document Type
Journal Article
Email Address
Lori.Cragin@state.vt.us
Funding Type
Cooperative Agreement; Agriculture
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-008085; B12212011
Issue of Publication
8
ISSN
0013-9351
NIOSH Division
DART
Priority Area
Agriculture, Forestry and Fishing; Mining
Source Name
Environmental Research
State
CO; VT; OH; GA
Performing Organization
Colorado State University - Ft. Collins
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