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The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.

Authors
Kang-Sickel-J-CC; Butler-MA; Frame-L; Serdar-B; Chao-Y-CE; Egeghy-P; Rappaport-SM; Toennis-CA; Li-W; Borisova-T; French-JE; Nylander-French-LA
Source
Biomarkers 2011 Nov; 16(7):590-599
NIOSHTIC No.
20039947
Abstract
We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p?=?0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p?
Keywords
Exposure-limits; Exposure-levels; Skin; Skin-exposure; Skin-irritants; Skin-sensitivity; Urinalysis; Naphthalenes; Biomarkers; Fuels; Author Keywords: Biomarkers; CYP2E1; dermal exposure; glutathione S-transferase mu 1 (GSTM1); glutathione S-transferase theta 1 (GSTT1); jet fuel (JP-8); keratin adduct; NAD(P)H:quinone oxidoreductase (NQO1); 1-naphthol; 2-naphthol; naphthalene; urine
Contact
Leena A. Nylander-French, Ph.D., CIH, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
CODEN
BIOMFA
CAS No.
91-20-3
Publication Date
20111101
Document Type
Journal Article
Email Address
leena_french@unc.edu
Funding Type
Grant
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-CCT-422952; Grant-Number-T42-OH-008673; B11232011
Issue of Publication
7
ISSN
1354-750X
NIOSH Division
DART
Priority Area
Healthcare and Social Assistance; Services; Manufacturing
Source Name
Biomarkers
State
CO; CA; NC; OH; TX
Performing Organization
University of North Carolina, Chapel Hill
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