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Mathematical models of skin permeability: an overview.

Authors
Mitragotri-S; Anissimov-YG; Bunge-AL; Frasch-HF; Guy-RH; Hadgraft-J; Kasting-GB; Lane-ME; Roberts-MS
Source
Int J Pharm 2011 Oct; 418(1):115-129
NIOSHTIC No.
20039915
Abstract
Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure-permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects.
Keywords
Drug-therapy; Mathematical-models; Models; Quantitative-analysis; Skin-absorption; Statistical-analysis; Women; Work-environment; Workplace-studies; Author Keywords: Transdermal; Stratum corneum; Permeability; Model; Theory; Mathematical; Exposure assessment
Contact
Samir Mitragotri, Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 USA
CODEN
IJPHDE
Publication Date
20111010
Document Type
Journal Article
Email Address
samir@engineering.ucsb.edu
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B11232011
Issue of Publication
1
ISSN
0378-5173
NIOSH Division
HELD
Source Name
International Journal of Pharmaceutics
State
CA; CO; WV; OH
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