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Pulmonary function and left ventricular mass in African Americans: The Atherosclerosis Risk in Communities (ARIC) study.

Authors
Charles-LE; Burchfiel-CM; Andrew-ME; Gu-JK; Petrini-MF; Butler-KR Jr.
Source
Echocardiography 2012 Feb; 29(2):131-139
NIOSHTIC No.
20039912
Abstract
Purpose: Impaired pulmonary function has been associated with increased cardiovascular disease incidence and mortality. The objective of this study was to investigate associations between pulmonary function and left ventricular (LV) mass. Methods: Participants were African American women (n = 1,069) and men (n = 555) aged 49-73 years, from the Atherosclerosis Risk in Communities study. Mean pulmonary function values at the first (1987-1989) and second (1990-1992) examinations were used. Echocardiograms were performed at the third and early in the fourth examinations (1993-1996). Analysis of covariance and linear regression were used to assess associations. Results: Mean levels of LV mass decreased with increasing quintiles of forced expiratory volume in one second (FEV1) among female never smokers (P = 0.039). Forced vital capacity (FVC) showed stronger associations than FEV1 with LV mass. Among men, LV mass was positively associated with FEV1 among current and never smokers, and with FVC among never smokers. Additional analyses among never smokers revealed significant inverse associations between LV mass and FVC among women with waist-to-hip ratios of >0.85 and those with no history of diabetes. In contrast, significant positive associations between LV mass and FVC were seen among male never smokers with body mass index (BMI) of =24.9 kg/m2, waist-to-hip ratios of =0.95, no history of hypertension or diabetes, and =60 years old. BMI and waist-to-hip ratio significantly modified associations among men. Conclusions: Among never smokers, LV mass and pulmonary function were inversely associated among women and positively associated among men. Further studies are warranted.
Keywords
Cardiovascular-function; Cardiovascular-system; Cardiovascular-system-disorders; Heart; Mathematical-models; Physiological-factors; Pulmonary-function; Pulmonary-system-disorders; Quantitative-analysis; Racial-factors; Risk-factors; Sex-factors; Statistical-analysis; Weight-factors; Weight-measurement; Author Keywords: left ventricular mass; pulmonary function; cardiovascular disease; African Americans
Contact
Luenda E. Charles, Ph.D., M.P.H., National Institute for Occupational Safety and Health, HELD/BEB, Mail Stop l-4050, 1095 Willowdale Rd., Morgantown, WV 26505-2888
CODEN
ECAGEE
Publication Date
20120201
Document Type
Journal Article
Email Address
Icharles@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B11232011
Issue of Publication
2
ISSN
0742-2822
NIOSH Division
HELD
Source Name
Echocardiography
State
WV; MS
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