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Moderate alcohol consumption and 24-hour urinary levels of melatonin in postmenopausal women.

Authors
Hartman-TJ; Mahabir-S; Baer-DJ; Stevens-RG; Albert-PS; Dorgan-JF; Kesner-JS; Meadows-JW; Shields-R; Taylor-PR
Source
J Clin Endocrinol Metab 2012 Jan; 97(1):E65-E68
NIOSHTIC No.
20039847
Abstract
Context: Low overnight urinary melatonin metabolite concentrations have been associated with increased risk for breast cancer among postmenopausal women. The Postmenopausal Women's Alcohol Study was a controlled feeding study to test the effects of low to moderate alcohol intake on potential risk factors for breast cancer including serum and urinary levels of hormones and other biomarkers. Previously, we observed significant increases in concentrations of serum estrone sulfate and dehydroepiandrosterone sulfate in participants after consumption of 15 or 30 g (one or two drinks) of alcohol per day. Objective: In the present analysis, we evaluated the relationship of alcohol consumption with 24-h urinary 6-sulfatoxymelatonin (6-SMT) concentration (micrograms per 24 h). Design and Participants: Healthy postmenopausal women (n = 51) consumed a controlled diet plus each of three treatments (a nonalcoholic placebo beverage or 15 or 30 g alcohol/d) during three 8-wk periods in random order under conditions of weight maintenance. Measures: 6-SMT was measured in 24-h urine samples that were collected at entry into the study (baseline) and at the midpoint (4 wk) and end (8 wk) of each of the three diet periods. Results: Concentration of 6-SMT was not significantly modified by the alcohol treatment after adjustment for body mass index, hours of sleep, daylight hours, and baseline level of 6-SMT. Conclusions: These results suggest that low to moderate daily alcohol consumption does not significantly affect 24-h urinary levels of melatonin among healthy postmenopausal women.
Keywords
Humans; Women; Metabolites; Age-groups; Urine-chemistry; Breast-cancer; Cancer; Alcoholic-beverages; Hormones; Hormone-activity
Contact
Terry Hartman, 110 Chandlee Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802
CODEN
JCEMAZ
Publication Date
20120101
Document Type
Journal Article
Email Address
tjh9@psu.edu
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B11122011
Issue of Publication
1
ISSN
0021-972X
NIOSH Division
DART
Priority Area
Agriculture, Forestry and Fishing; Mining
Source Name
Journal of Clinical Endocrinology and Metabolism
State
CT; MD; OH; PA
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