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Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.

Authors
Silbergeld-EK; Contreras-EQ; Hartung-T; Hirsch-C; Hogberg-H; Jachak-AC; Jordan-W; Landsiedel-R; Morris-J; Patri-A; Pounds-JG; Ruiz-AD; Shvedova-A; Tanguay-R; Tatarazako-N; van Vliet-E; Walker-NJ; Wiesner-M; Wilcox-N; Zurlo-J
Source
ALTEX 2011 Mar; 28(3):236-241
NIOSHTIC No.
20039842
Abstract
In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information.
Keywords
Nanotechnology; Safety-measures; Toxicology; Animals; Toxic-effects; Toxins; Author Keywords: nanomaterials; nanotoxicology; alternative methods; 3Rs; Tox-21c
Contact
Joanne Zurlo, PhD The Johns Hopkins Center for Alternatives to Animal Testing, 615 North Wolfe Street, W7032, Baltimore, MD 21205
Publication Date
20110301
Document Type
Journal Article
Email Address
jzurlo@jhsph.edu
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
B11122011
Issue of Publication
3
ISSN
1868-596X
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
ALTEX Alternatives to Animal Experimentation
State
DC; MD; NC; OR; TX; WA; WV
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