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Potential immunotoxicological health effects following exposure to COREXIT 9500A during cleanup of the Deepwater Horizon oil spill.

Authors
Anderson-SE; Franko-J; Lukomska-E; Meade-BJ
Source
J Toxicol Environ Health, A 2011 Nov; 74(21):1419-1430
NIOSHTIC No.
20039684
Abstract
Workers involved in the Deepwater Horizon oil spill cleanup efforts reported acute pulmonary and dermatological adverse health effects. These studies were undertaken to assess the immunotoxicity of COREXIT 9500A, the primary dispersant used in cleanup efforts, as a potential causative agent. COREXIT 9500A and one of its active ingredients, dioctyl sodium sulfosuccinate (DSS), were evaluated using murine models for hypersensitivity and immune suppression, including the local lymph node assay (LLNA), phenotypic analysis of draining lymph node cells (DLN), mouse ear swelling test (MEST), total serum immunoglobulin E (IgE), and the plaque-forming cell (PFC) assay. Dermal exposure to COREXIT 9500A and DSS induced dose-responsive increases in dermal irritation and lymphocyte proliferation. The EC3 values for COREXIT 9500A and DSS were 0.4 percent and 3.9 percent, respectively, resulting in a classification of COREXIT 9500A as a potent sensitizer and DSS as a moderate sensitizer. A T-cell-mediated mechanism underlying the LLNA was supported by positive responses in the MEST assay for COREXIT and DSS, indicated by a significant increase in ear swelling 48 h post challenge. There were no marked alterations in total serum IgE or B220+/IgE+ lymph-node cell populations following exposure to COREXIT 9500A. Significant elevations in interferon (IFN)-gamma but not interleukin (IL)-4 protein were also observed in stimulated lymph node cells. The absence of increases in IgE and IL-4 in the presence of enhanced lymphocyte proliferation, positive MEST responses, and elevations in IFN-gamma suggest a T-cell-mediated mechanism. COREXIT 9500A did not induce immunosuppression in the murine model.
Keywords
Emergency-response; Emergency-responders; Environmental-pollution; Employee-exposure; Employee-health; Environmental-contamination; Environmental-exposure; Oil-industry; Oil-refineries; Oil-refinery-workers; Respiratory-system-disorders; Pulmonary-system-disorders; Dermatitis; Dermatosis; Skin-disorders; Skin-exposure; Decontamination; Dispersion; Immune-reaction; Immune-system; Immunotoxins; Hypersensitivity; Bioassays; Lymph-nodes; Dose-response; Lymphocytes; Cell-function; Cellular-reactions; Chemical-hypersensitivity; Immunoglobulins; Petroleum-industry; Petroleum-oils; Petroleum-products; Petroleum-refineries; Sensitization; Sodium-compounds; Blood-serum
Contact
Stacey E. Anderson, PhD, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JTEHD6
CAS No.
1338-43-8; 9005-65-6; 9005-70-3; 577-11-7; 29911-28-2; 64742-47-8
Publication Date
20111101
Document Type
Journal Article
Email Address
Sanderson4@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B10122011
Issue of Publication
21
ISSN
1528-7394
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
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