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A computer-controlled whole-body inhalation exposure system for the oil dispersant COREXIT EC9500A.

Authors
Goldsmith-WT; McKinney-W; Jackson-M; Law-B; Bledsoe-T; Siegel-P; Cumpston-J; Frazer-D
Source
J Toxicol Environ Health, A 2011 Nov; 74(21):1368-1380
NIOSHTIC No.
20039675
Abstract
An automated whole-body inhalation exposure system capable of exposing 12 individually housed rats was designed to examine the potential adverse health effects of the oil dispersant COREXIT EC9500A, used extensively during the Deepwater Horizon oil spill. A computer-controlled syringe pump injected the COREXIT EC9500A into an atomizer where droplets and vapor were formed and mixed with diluent air. The aerosolized COREXIT EC9500A was passed into a customized exposure chamber where a calibrated light-scattering instrument estimated the real-time particle mass concentration of the aerosol in the chamber. Software feedback loops controlled the chamber aerosol concentration and pressure throughout each exposure. The particle size distribution of the dispersant aerosol was measured and shown to have a count median aerodynamic diameter of 285 nm with a geometric standard deviation of 1.7. The total chamber concentration (particulate + vapor) was determined using a modification of the acidified methylene blue spectrophotometric assay for anionic surfactants. Tests were conducted to show the effectiveness of closed loop control of chamber concentration and to verify chamber concentration homogeneity. Five automated 5-h animal exposures were performed that produced controlled and consistent COREXIT EC9500A concentrations (27.1 +/- 2.9 mg/m3, mean +/- SD).
Keywords
Aerosol-particles; Airborne-particles; Animals; Animal-studies; Inhalation-studies; Laboratory-animals; Laboratory-testing; Exposure-chambers; Exposure-methods; Oil spills; Hazardous waste cleanup; Chemical agents; Chemical analysis
Contact
William Travis Goldsmith, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JTEHD6
CAS No.
1338-43-8; 9005-65-6; 9005-70-3; 577-11-7; 29911-28-2; 64742-47-8
Publication Date
20111114
Document Type
Journal Article
Email Address
Wbg4@cdc.gov
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Identifying No.
B10122011
Issue of Publication
21
ISSN
1528-7394
NIOSH Division
HELD
Priority Area
Construction; Manufacturing
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
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