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Performance of a human inhalation challenge exposure system. I. Gases.

Authors
Hammad-YY; Pieretti-LF
Source
Inhal Toxicol 2011 May; 23(6):331-338
NIOSHTIC No.
20039647
Abstract
The purpose of this study was to characterize and evaluate the performance of a whole-body human exposure chamber for controlled test atmospheres of gases and particulates. This article is a report on the performance of the system with gas phase agents. Results of the performance of the system with particulate phase agents will be presented in a separate report. The chamber was constructed from Plexiglas with a volume of 2.13 m(3) (75 ft(3)) and operating at a flow rate about 1.0 m(3)/min (34 cfm). Both the makeup and exhaust air were HEPA-filtered. CO(2) was used as a tracer gas and its concentration was measured using Metrosonics aq-5000 instruments. The CO(2) concentrations used in this study ranged from about 5000 to 12,000 ppm. Observed and predicted concentrations at equilibrium of test material were in agreement within 1.7 percent. Concentration of CO(2) was found to be even horizontally throughout the chamber, with a small initial lag of about 30 sec between the maximum concentration at the top and the bottom of the chamber. The system can thus be reliably used for inhalation challenge procedures for gases.
Keywords
Gases; Inhalants; Particulates; Laboratory-testing; Exposure-assessment; Exposure-chambers; Controlled-atmospheres; Equipment-reliability; Performance-capability; Control-systems; Air-flow; Measurement-equipment; Testing-equipment; Exhaust-gases; Humans; Author Keywords: Exposure chamber; human challenge; gaseous agents
Contact
Yehia Y. Hammad, College of Public Health, 13201 Bruce B. Downs Blvd, Tampa, FL 33612, USA
CODEN
INHTE5
CAS No.
124-38-9
Publication Date
20110501
Document Type
Journal Article
Email Address
yhammad@health.usf.edu
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008438; B09282011
Issue of Publication
6
ISSN
0895-8378
Source Name
Inhalation Toxicology
State
FL
Performing Organization
Sunshine Education and Research Center, University of South Florida
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