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Diabetes, impaired glucose tolerance, and metabolic biomarkers in individuals with normal glucose tolerance are inversely associated with lung function: The Jackson Heart Study.

Authors
Hickson-DA; Burchfiel-CM; Liu-J-K; Petrini-MF; Harrison-K; White-WB; Sarpong-DF
Source
Lung 2011 Aug; 189(4):311-321
NIOSHTIC No.
20039633
Abstract
The objectives of this study were to test the hypothesis that diabetes and impaired glucose tolerance (IGT), diabetes control and diabetes duration, and metabolic biomarkers in adults with normal glucose tolerance (NGT) are inversely associated with spirometry-measured lung function. We conducted a cross-sectional observational cohort study that included nonsmoking African American adults (n = 2,945; mean age = 52.5 + / - 12.6 years; 69.2 percent female), who were free of cardiovascular disease, from the Jackson Heart Study. The interventions were diabetes, metabolic biomarkers and lung function. We measured the associations of glycemia with forced expiratory volume (FEV) in 1 s, FEV in 6 s, and vital capacity. Multivariable adjusted mean lung function values were lower among adults with diabetes and IGT (in women only, but not after adjustment for waist circumference) than adults with NGT. Among adults with diabetes, no associations were observed between lung function and diabetes control or duration. In women with NGT, lower lung function was consistently associated with higher glucose levels and less consistently with higher insulin levels and insulin resistance. Lower lung function was consistently associated with higher insulin levels and insulin resistance and less consistently associated with insulin and hemoglobin A1c in men with NGT. Overall, our findings generally support the hypothesis that diabetes, IGT, and increased levels of metabolic biomarkers in individuals with NGT are inversely associated with lung function in African Americans, independent of adiposity.
Keywords
Respiration; Respiratory-function-tests; Respiratory-rate; Spirometry; Pulmonary-function; Pulmonary-function-tests; Lung-function; Metabolic-activation; Metabolic-disorders; Metabolic-rate; Metabolic-study; Metabolism; Biomarkers; Sugars; Racial-factors; Men; Women; Biological-effects; Biological-function; Breathing; Vital-capacity; Author Keywords: Forced expiratory volume in 1 s; Insulin resistance; Spirometry; Vital capacity; Impaired glucose tolerance
Contact
D. A. Hickson, Jackson State University, Jackson Heart Study, 350 W Woodrow Wilson Ave., Suite 701, Jackson, MS 39213 USA
CODEN
LUNGD9
Publication Date
20110801
Document Type
Journal Article
Email Address
demarc.a.hickson@jsums.edu
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
B09282011
Issue of Publication
4
ISSN
0341-2040
NIOSH Division
HELD
Source Name
Lung
State
MS; WV
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