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Occupational exposure to anesthetic gases, antineoplastic drugs, antiviral drugs, sterilizing agents, and x-rays and risk of spontaneous abortion among nurses.

Authors
Lawson-CC; Rocheleau-CM; Whelan-EA; Hibert-EN; Grajewski-B; Spiegelman-D; Rich-Edwards-JW
Source
Am J Epidemiol 2011 Jun; 173(Suppl 11):S296
NIOSHTIC No.
20039630
Abstract
Adverse reproductive outcomes among female health care workers have been reported, but previous studies have been of limited sample size. We evaluated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents, and X-rays and the risk of spontaneous abortion (SA) in U.S. nurses. Retrospective data on pregnancy outcome, occupational exposures, work schedule, and lifestyle factors were collected from 7,482 participants of the Nurses' Health Study II who worked as a nurse during the first trimester of pregnancy. The overall participation rate was 76%. Log binomial regression was used to estimate relative risks (RRs) and 95% confidence intervals (95% CI). Participants reported 6,707 live births and 775 (10%) SAs (< 20 weeks gestation), 74% of occurred before the 12th week of pregnancy. After adjusting for age, parity, shift work, and hours worked per week, reported exposure to antineoplastic drugs was associated with an increased risk of SA (RR = 1.86, 95% CI = 1.27-2.73); particularly with early SA of < 12 weeks gestation (RR = 2.04, 95% CI = 1.33-3.13). Reported exposure to sterilizing agents was associated with a 2-fold increased risk of late SA (12-20 weeks) (95% CI = 1.28-3.93), but not with early SA. There was a suggested increase in risk of early SA with X-ray exposure (1.29; 0.99-1.68). Antiviral drug and anesthetic gas exposures were not associated with SA in our study. This study suggests that occupational exposures to antineoplastic drugs and sterilizing agents are related to an increased risk of SA.
Keywords
Biohazards; Drugs; Health-care-personnel; Mathematical-models; Pregnancy; Reproductive-effects; Reproductive-hazards; Reproductive-system; Reproductive-system-disorders; Risk-analysis; Work-areas; Worker-health; Work-operations; Antineoplastic-agents; Anesthetics
CODEN
AJEPAS
Publication Date
20110601
Document Type
Abstract
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
B09282011
ISSN
0002-9262
NIOSH Division
DSHEFS
Priority Area
Healthcare and Social Assistance
Source Name
American Journal of Epidemiology
State
OH; MA
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