Sarcoidosis diagnosed after September 11, 2001, among adults exposed to the World Trade Center disaster.
Jordan-HT; Stellman-SD; Prezant-D; Teirstein-A; Osahan-SS; Cone-JE
J Occup Environ Med 2011 Sep; 53(9):966-974
Objective: Explore relationships between World Trade Center (WTC) exposures and sarcoidosis. Methods: Sarcoidosis has been reported after exposure to the WTC disaster. We ascertained biopsy-proven post-9/11 sarcoidosis among WTC Health Registry enrollees. Cases diagnosed after Registry enrollment were included in a nested case-control study. Controls were matched to cases on age, sex, race or ethnicity, and eligibility group (eg, rescue or recovery worker). Results: We identified 43 cases of post-9/11 sarcoidosis. Twenty-eight incident cases and 109 controls were included in the case-control analysis. Working on the WTC debris pile was associated with sarcoidosis (odds ratio 9.1, 95 percent confidence interval 1.1 to 74.0), but WTC dust cloud exposure was not (odds ratio 1.0, 95 percent confidence interval 0.4 to 2.8). Conclusions: Working on the WTC debris pile was associated with an elevated risk of post-9/11 sarcoidosis. Occupationally exposed workers may be at increased risk.
Biological-effects; Biological-monitoring; Case-studies; Demographic-characteristics; Risk-analysis; Risk-factors; Emergency-responders; Emergency-response; Employee-exposure; Employee-health; Rescue-workers; Biopsy; Disease-incidence; Exposure-assessment; Organs; Tissue-disorders; Skin; Lung; Lymph-nodes; Eyes; Cell-function; Immune-reaction; Immune-system; Immune-system-disorders; Cell-alteration; Cell-cultures; Cell-damage; Corticosteroids
Hannah T. Jordan, MD, or James E. Cone, MD, World Trade Center Health Registry, New York City Department of Health and Mental Hygiene, 42-09 28th St, 7th floor, Long Island City, NY 11101
Cooperative-Agreement-Number-U10-OH-008243; B09282011; Cooperative-Agreement-Number-U10-OH-008242; Cooperative-Agreement-Number-U50-TS-272750; Cooperative-Agreement-Number-U50-OH-009739
Journal of Occupational and Environmental Medicine
New York City Fire Department