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Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study.

Authors
Ren-C; Fang-S; Wright-RO; Suh-H; Schwartz-J
Source
Occup Environ Med 2011 Aug; 68(8):562-569
NIOSHTIC No.
20039596
Abstract
Background: Studies show that exposure to air pollution damages human health, but the mechanisms are not fully understood. One suggested pathway is via oxidative stress. Objectives: This study examines associations between exposure to air pollution and oxidative DNA damage, as indicated by urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations in ageing participants during 2006-2008. Methods: We fit linear regression models to examine associations between air pollutants and 8-OHdG adjusting for potential confounders. Results: 8-OHdG was significantly associated with ambient particulate matter =2.5 m in aerodynamic diameter (PM2.5), nitrogen dioxide (NO2), maximal 1 h ozone (O3), sulphate (SO42-) and organic carbon (OC), but not with black carbon (BC), carbon monoxide (CO), the number of particles (PN) or elemental carbon (EC). Effects were more apparent with multi-week averages of exposures. Per IQR increases in 21-day averages of PM2.5, PN, BC, EC, OC, CO, SO42-, NO2 and maximal 1 h O3 were associated with 30.8% (95% CI 9.3% to 52.2%), -13.1% (95% CI -41.7% to 15.5%), 3.0% (95% CI -19.8% to 25.8%), 5.3% (95% CI -23.6% to 34.2%), 24.4% (95% CI 1.8% to 47.1%), -2.0% (95% CI -12.4% to 8.3%), 29.8% (95% CI 6.3% to 53.3%), 32.2% (95% CI 7.4% to 56.9%) and 47.7% (95% CI 3.6% to 91.7%) changes in 8-OHdG, respectively. Conclusions: This study suggests that ageing participants experienced an increased risk of developing oxidative DNA injury after exposure to secondary, but not primary, ambient pollutants.
Keywords
Age-factors; Airborne-particles; Analytical-methods; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Molecular-biology; Oxidation; Oxidative-metabolism; Oxidative-processes; Particle-aerodynamics; Particulates; Particulates; Pollutants; Statistical-analysis; Urine-chemistry
Contact
Cizao Ren, Department of Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Landmark Center, West, Suite 415, PO Box 15677, 401 Park Dr., Boston, MA 02215, USA
CODEN
OEMEEM
CAS No.
10102-44-0; 1333-86-4; 630-08-0; 7440-44-0
Publication Date
20110801
Document Type
Journal Article
Email Address
rencizao@yahoo.com
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008416; B09282011
Issue of Publication
8
ISSN
1351-0711
Source Name
Occupational and Environmental Medicine
State
MA
Performing Organization
Harvard School of Public Health
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