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Lab-on-a-chip sensor for detection of highly electronegative heavy metals by anodic stripping voltammetry.

Authors
Jothimuthu-P; Wilson-RA; Herren-J; Haynes-EN; Heineman-WR; Papautsky-I
Source
Biomed Microdevices 2011 Aug; 13(4):695-703
NIOSHTIC No.
20039582
Abstract
This work describes development of a lab-on-a-chip sensor for electrochemical detection of highly electronegative heavy metals such as manganese and zinc by anodic stripping voltammetry. The sensor consists of a three-electrode system, with a bismuth working electrode, a Ag/AgCl reference electrode, and a Au auxiliary electrode. Hydrolysis at the auxiliary electrode is a critical challenge in such electrochemical sensors as its onset severely limits the ability to detect electronegative metals. The bismuth working electrode is used due to its comparable negative detection window and reduced toxicity with respect to a conventional mercury electrode. Through optimization of the sensor layout and the working electrode surface, effects of hydrolysis were substantially reduced and the potential window was extended to the -0.3 to -1.9 V range (vs. Ag/AgCl reference electrode), which is far more negative than what is possible with conventional Au, Pt, or carbon electrodes. The described lab-on-a-chip sensor for the first time permits reliable and sensitive detection of the highly electronegative manganese. The favorable performance of the bismuth electrode coupled with its environmentally-friendly nature make the described sensor attractive for applications where disposable chips are desirable. With further development and integrated sample preparation, the lab-on-a-chip may be converted into a point-of-care platform for monitoring heavy metals in blood (e.g., assessment of manganese exposure).
Keywords
Heavy-metals; Detectors; Laboratory-equipment; Laboratory-techniques; Computer-equipment; Electronic-devices; Electrochemistry; Manganese-compounds; Zinc-compounds; Heavy-metals; Metal-compounds; Metals; Sample-preparation; Sampling-equipment; Sampling-methods; Blood-samples; Blood-sampling; Biological-monitoring; Author Keywords: Electrochemical sensor; Bismuth electrodes; Anodic stripping voltammetry; Heavy metal detection; Lab-on-a-chip
Contact
Ian Papautsky, BioMicroSystems Laboratory, School of Electronics and Computing Systems, 814 Rhodes Hall, ML030, University of Cincinnati, Cincinnati, OH 45221, USA
CODEN
BMICFC
CAS No.
7439-96-5; 7440-66-6; 7440-69-9
Publication Date
20110801
Document Type
Journal Article
Email Address
Ian.Papautsky@uc.edu
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008432; B09282011
Issue of Publication
4
ISSN
1387-2176
Source Name
Biomedical Microdevices
State
OH
Performing Organization
University of Cincinnati
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