Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Sensitization and chronic beryllium disease at a primary manufacturing facility, part 3: exposure-response among short-term workers.

Authors
Schuler-CR; Virji-MA; Deubner-DC; Stanton-ML; Stefaniak-AB; Day-GA; Park-JY; Kent-MS; Sparks-R; Kreiss-K
Source
Scand J Work, Environ & Health 2012 Jun; 38(3):270-281
NIOSHTIC No.
20039555
Abstract
Objectives: Exposure-response relations for beryllium sensitization (BeS) and chronic beryllium disease (CBD) using aerosol mass concentration have been inconsistent, although process-related risks found in most studies suggest that exposure-dependent risks exist. We examined exposure-response relations using personal exposure estimates in a beryllium worker cohort with limited work tenure to minimize exposure misclassification. Methods: The population comprised workers employed in 1999 with six years or less tenure. Each completed a work history questionnaire and was evaluated for immunological sensitization and CBD. A job-exposure matrix was combined with work histories to create individual estimates of average, cumulative, and highest-job-worked exposure for total, respirable, and submicron beryllium mass concentrations. We obtained odds ratios from logistic regression models for exposure-response relations, and evaluated process-related risks. Results: Participation was 90.7% (264/291 eligible). Sensitization prevalence was 9.8% (26/264), with 6 sensitized also diagnosed with CBD (2.3%, 6/264). A general pattern of increasing sensitization prevalence was observed as exposure quartile increased. Both total and respirable beryllium mass concentration estimates were positively associated with sensitization (average and highest job), and CBD (cumulative). Increased sensitization prevalence was identified in metal/oxide production, alloy melting and casting, and maintenance, and for CBD in melting and casting. Lower sensitization prevalence was observed in plant-area administrative work. Conclusion:s Sensitization was associated with average and highest job exposures, and CBD was associated with cumulative exposure. Both total and respirable mass concentrations were relevant predictors of risk. New process-related risks were identified in melting and casting and maintenance.
Keywords
Airborne-particles; Air-quality-measurement; Air-sampling-techniques; Beryllium-compounds; Beryllium-disease; Biological-effects; Cardiovascular-system; Chronic-exposure; Exposure-assessment; Exposure-levels; Lung-function; Mathematical-models; Microscopic-analysis; Physical-properties; Physiological-effects; Physiological-measurements; Physiological-response; Pulmonary-function; Pulmonary-system; Quantitative-analysis; Respiratory-hypersensitivity; Respiratory-irritants; Risk-analysis; Risk-factors; Work-environment; Workplace-studies; Author Keywords: average exposure; beryllium; beryllium disease; chronic beryllium disease; cumulative exposure; exposure-response; manufacturing; occupational respiratory disease; peak exposure; sensitization; worker
CODEN
SWEHDO
CAS No.
7440-41-7
Publication Date
20120601
Document Type
Journal Article
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0355-3140
NIOSH Division
DRDS
Priority Area
Manufacturing
Source Name
Scandinavian Journal of Work, Environment and Health
State
WV; OH
TOP