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Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia.

Authors
Kan-H; Wu-Z; Young-S-H; Chen-T-H; Cumpston-JL; Chen-F; Kashon-ML; Castranova-V
Source
Nanotoxicology 2012 Nov; 6(7):736-745
NIOSHTIC No.
20039554
Abstract
The inhalation of engineered nanoparticles stimulates the development of atherosclerosis and impairs vascular function. However, the cardiac effects of inhaled engineered nanoparticles are unknown. Here, we investigate the effects of ultrafine titanium dioxide (UFTiO2) on the heart, and we define the possible mechanisms underlying the measured effects. Pulmonary exposure of rats to UFTiO2 increased the phosphorylation levels of p38 mitogen-activated protein kinase and cardiac troponin I, but not Akt, in the heart and substance P synthesis in nodose ganglia. Circulatory levels of proinflammatory cytokines, and blood cell counts and differentials were not significantly changed after pulmonary exposure. Separately, the incubation of cardiac myocytes isolated from na´ve adult rat hearts in vitro with UFTiO2 did not alter the phosphorylation status of the same cardiac proteins. In conclusion, the inhalation of UFTiO2 enhanced the phosphorylation levels of cardiac proteins. Such responses are likely independent of systemic inflammation, but may involve a lung-neuron-regulated pathway.
Keywords
Airborne-particles; Biological-effects; Cardiovascular-system; Exposure-assessment; Inhalation-studies; Laboratory-animals; Laboratory-testing; Lung-function; Microscopic-analysis; Nanotechnology; Particle-aerodynamics; Particulates; Physical-properties; Physiological-effects; Physiological-measurements; Physiological-response; Pulmonary-function; Pulmonary-system; Quantitative-analysis; Respiratory-hypersensitivity; Vasoactive-agents; Author Keywords: Nanoparticles; cardiovascular diseases; titanium dioxide; inhalation study
Contact
Hong Kan, PPRB/NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
CAS No.
13463-67-7
Publication Date
20121101
Document Type
Journal Article
Email Address
hvn4@cdc.gov
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1743-5390
NIOSH Division
HELD
Source Name
Nanotoxicology
State
WV
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