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Nanomaterials in humans: identification, characteristics, and potential damage.

Authors
Song-YG; Li-X; Wang-LY; Rojanasakul-Y; Castranova-V; Li-HL; Ma-J
Source
Toxicol Pathol 2011 Aug; 39(5):841-849
NIOSHTIC No.
20039455
Abstract
Nanomaterials are increasingly being used for commercial purposes. However, concerns about the potential risks of exposure to humans have been raised. We previously reported unusual pulmonary disease and death in a group of patients with occupational exposure to spray paint. However, the nanoparticle and chemical composition of the exposure was not fully described. The present study aimed to isolate and identify the nanoparticles observed in the patients' biopsies and report the potential deleterious effects to human lungs using electron microscopy. Using electron microscopy and energy dispersive x-ray analysis, silica nanoparticles were identified and characterized mainly in macrophages, pulmonary microvessels, vascular endothelial cells, microlymphatic vessels, pleural effusions, and a few in alveolar epithelial cells and pulmonary interstitial tissue (with no microscale particles present). Notably, damage to alveolar epithelial cells, macrophages, vascular endothelial cells, and the blood-gas barrier was observed. Given the well-documented toxicity of microscale silica, it is possible that these silica nanoparticles may have contributed in part to the illness reported in these workers. Such a possibility supports the adoption of controls and prevention strategies to minimize inhalation of nanoparticles by workers, and it highlights the urgent need and the importance of the nanosafety study in humans.
Keywords
Nanotechnology; Nanoparticles; Humans; Biopsy; Pathology; Biological-effects; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Microscopic-analysis; Microscopy; X-ray-analysis; Silica-dusts; Pleural-cavity; Pulmonary-function; Lung-cells; Lung-tissue; Alveolar-cells; Cell-damage; Toxic-effects; Toxic-materials; Safety-research; Paints; Fibrosis; Author Keywords: human; pleural effusion; pulmonary fibrosis; silica nanoparticle
Contact
YG Song, Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Occupat Med & Clin Toxicol, 8 Gongtinan Rd, Beijing 100020, Peoples R China
CODEN
TOPADD
CAS No.
7631-86-9; 14808-60-7
Publication Date
20110801
Document Type
Journal Article
Email Address
songrain123@hotmail.com
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0192-6233
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Toxicologic Pathology
State
WV
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