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Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides.

Authors
Ahn-KC; Kim-H-J; McCoy-MR; Gee-SJ; Hammock-BD
Source
J Agric Food Chem 2011 Apr; 59(7):2792-2802
NIOSHTIC No.
20039406
Abstract
This paper describes some of the early work on pyrethroid insecticides in the Casida laboratory and briefly reviews the development and application of immunochemical approaches for the detection of pyrethroid insecticides and their metabolites for monitoring environmental and human exposure. Multiple technologies can be combined to enhance the sensitivity and speed of immunochemical analysis. The pyrethroid assays are used to illustrate the use of some of these immunoreagents such as antibodies, competitive mimics, and novel binding agents such as phage-displayed peptides. The paper also illustrates reporters such as fluorescent dyes, chemiluminescent compounds, and luminescent lanthanide nanoparticles, as well as the application of magnetic separation, and automatic instrumental systems, biosensors, and novel immunological technologies. These new technologies alone and in combination result in an improved ability to both determine if effective levels of pyrethroids are being used in the field and evaluate possible contamination.
Keywords
Environmental-exposure; Insecticides; Pesticides; Pesticides-and-agricultural-chemicals; Humans; Men; Women; Analytical-methods; Body-fluids; Exposure-levels; Exposure-limits; Immunochemistry; Author Keywords: Pyrethroid insecticides; Immunoassay; Biosensors; Monitoring
Contact
Bruce D. Hammock, Department of Entomology, University of California, Davis, Davis, California 95616
CODEN
JAFCAU
Publication Date
20110401
Document Type
Journal Article
Email Address
bdhammock@ucdavis.edu
Funding Type
Cooperative Agreement; Agriculture
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007550
Issue of Publication
7
ISSN
0021-8561
Source Name
Journal of Agricultural and Food Chemistry
State
CA
Performing Organization
University of California - Davis
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