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In vitro human epidermal penetration of 1-bromopropane.

Authors
Frasch-HF; Dotson-GS; Barbero-AM
Source
J Toxicol Environ Health, A 2011 Aug; 74(19):1249-1260
NIOSHTIC No.
20039358
Abstract
1-Bromopropane (1-BP; CAS number 106-94-5), also known as n-propyl bromide, is a halogenated short-chain alkane used as an organic solvent with numerous commercial and industrial applications, including garment dry cleaning and vapor degreasing of metals. The purpose of this study was to determine the dermal absorption characteristics and corrosivity of 1-BP. Heat-separated human epidermal membranes were mounted on static diffusion cells. Different exposure scenarios were studied (infinite dose, finite dose, and transient exposure) using neat 1-BP and saturated aqueous solution as donor. Steady-state fluxes for infinite-dose neat 1-BP exposure averaged 625 to 960 mu g cm(-2) h(-1). The finite-dose (10 mu l/cm(2) = 13.5 mg/cm(2)) unoccluded donor resulted in penetration of <0.2% of the applied dose (22 mu g/cm(2)). A 10-min transient exposure to infinite dose resulted in total penetration of 179 mu g/cm(2). Steady-state 1-BP fluxes from neat application of a commercial dry cleaning solvent were similar (441 to 722 mu g cm(-2) h(-1)). The permeability coefficient of 1-BP in water vehicle was 0.257 +/- 0.141 cm/h. The absorption potential of 1-BP following dermal exposure is dependent upon the type and duration of exposure. Donor losses due to evaporation were approximately 500-fold greater than dermal absorption flux; evaporation flux was 420 mg cm(-2) h(-1). 1-BP is cytotoxic but not corrosive, based on results from a cultured reconstructed human epidermal model (EpiDerm Skin Corrosivity Test).
Keywords
Biohazards; Biological-effects; Biological-monitoring; Cell-biology; Cell-function; Cellular-reactions; Chemical-hypersensitivity; Chemical-properties; Corrosive-materials; Cytology; Cytopathology; Cytotoxic-effects; Dry-cleaning-industry; Dry-cleaning-solvents; Exposure-assessment; Exposure-levels; Immune-reaction; Mathematical-models; Pathology; Physiological-effects; Physiological-response; Quantitative-analysis; Skin-absorption; Skin-exposure; Statistical-analysis; Vapors; Work-areas; Worker-health; Work-operations
Contact
H. Frederick Frasch, NIOSH, HELD, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
JTEHD6
CAS No.
106-94-5
Publication Date
20110810
Document Type
Journal Article
Email Address
HFrasch@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
19
ISSN
1528-7394
NIOSH Division
HELD; EID
Priority Area
Manufacturing; Services
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV; OH
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