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Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate.

Authors
Flack-SL; Fent-KW; Gaines-LGT; Thomasen-JM; Whittaker-SG; Ball-LM; Nylander-French-LA
Source
Biomarkers 2011 May; 16(3):261-270
NIOSHTIC No.
20039326
Abstract
We investigated the utility of 1,6-hexamethylene diamine (HDA) hemoglobin adducts as biomarkers of exposure to 1,6-hexamethylene diisocyanate (HDI) monomer. Blood samples from 15 spray painters applying HDI-containing paint were analyzed for hemoglobin HDA (HDA-Hb) and N-acetyl-1,6-hexamethylene diamine (monoacetyl-HDA-Hb) by GC-MS. HDA-Hb was detected in the majority of workers (=1.2-37?ng/g Hb), whereas monoacetyl-HDA-Hb was detected in one worker (0.06?ng/g Hb). The stronger, positive association between HDA-Hb and cumulative HDI exposure (r(2)?=?0.3, p?
Keywords
Airborne-particles; Biological-effects; Chemical-hypersensitivity; Dermatitis; Exposure-assessment; Inhalants; Inhalation-studies; Paint-spraying; Particle-aerodynamics; Particulates; Quantitative-analysis; Respiratory-hypersensitivity; Respiratory-irritants; Statistical-analysis; Biomarkers; Author Keywords: 1,6-hexamethylene diamine (HDA); hemoglobin; adduct; biomarker; 1,6-hexamethylene diisocyanate (HDI)
Contact
Leena A. Nylander-French, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
CODEN
BIOMFA
CAS No.
822-06-0
Publication Date
20110501
Document Type
Journal Article
Email Address
leena_french@unc.edu
Funding Type
Grant; Cooperative Agreement
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007598; Cooperative-Agreement-Number-T42-CCT-422952; Grant-Number-R01-OH-009086
Issue of Publication
3
ISSN
1354-750X
Source Name
Biomarkers
State
WV; WA; NC
Performing Organization
University of North Carolina, Chapel Hill, North Carolina
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