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The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain.

Authors
Li-HY; Wu-SY; Ma-Q; Shi-N
Source
Toxicol Ind Health 2011 Aug; 27(7):579-590
NIOSHTIC No.
20039303
Abstract
The transcription factor NF-E2-related factor 2 (Nrf2) plays a critical role in the mammalian response to chemical and oxidative stress through induction of phase II detoxification enzymes and oxidative stress response proteins. We reported that Nrf2 expression was activated by deltamethrin (DM), a prototype of the widely used pyrithroid pesticides, in PC12 cells. However, no study has examined Nrf2 nuclear translocation and free radical production, two hallmarks of oxidative stress, in the mammalian brain in vivo. To this end, we examined translocation of Nrf2 and production of free radicals in rat brain exposed to DM. Indeed, DM initiated nuclear translocation of Nrf2 in a dose-dependent manner. Furthermore, Nrf2 translocation was accompanied by the expression of heme oxygenase-1 gene, an Nrf2-regulated gene linked to free radical production. Deltamethrin exposure promoted free radical formation in rat brain and reactive oxygen species generation in PC12 cells. Translocation of Nrf2 may be a response to DM-dependent induction of free radicals and DM may act as a mammalian neurotoxin by initiating oxidative stress.
Keywords
Brain-disorders; Brain-function; Chemical-hypersensitivity; Chemical-inhibition; Chemical-properties; Chemical-synthesis; Genes; Genetic-factors; Laboratory-animals; Laboratory-testing; Oxidation; Oxidative-metabolism; Oxidative-processes; Pesticides; Pesticides-and-agricultural-chemicals; Author Keywords: Deltamethrin; free radical; Nrf2; oxidative stress; neurotoxicity; in vivo
Contact
HY Li, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
CODEN
TIHEEC
Publication Date
20110801
Document Type
Journal Article
Email Address
snian@mails.tjmu.edu.cn
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
0748-2337
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Toxicology and Industrial Health
State
WV
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