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Factors governing pulmonary response to inhaled particulate matter.

Authors
Castranova-V
Source
Aerosol Measurement: Principles, Techniques, and Applications, Third Edition. Kulkarni P, Baron PA, Willeke K, eds., Hoboken, NJ: John Wiley and Sons, Inc, 2011 Jan; :793-803
NIOSHTIC No.
20039273
Abstract
The pulmonary response to an inhaled particle is influenced by its deposition fraction and the site of deposition. Pulmonary response would be minimized if the particle were rapidly cleared and be more pronounced if the particle had a high residence time in the lung. Once in the lung, the unique surface properties of a particle govern particle-cell interactions and affect the bioactivity and degree of pathogenicity of the particle. Nanoparticles are likely to exhibit greater adverse health effects than fine particles of the same composition due to their higher pulmonary deposition, their ability to enter the alveolar septa and perhaps the systemic circulation, and the role of particle surface area in affecting cellular toxicity.
Keywords
Airborne-particles; Biohazards; Biological-effects; Biological-factors; Biological-function; Biological-systems; Cell-biology; Cell-function; Cellular-function; Cellular-reactions; Health-hazards; Lung-cells; Lung-disorders; Lung-irritants; Nanotechnology; Particle-aerodynamics; Particulate-dust; Particulates; Physiological-chemistry; Physiological-effects; Physiological-function; Physiological-response; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Respiratory-hypersensitivity; Respiratory-irritants; Respiratory-system-disorders; Toxic-effects; Author Keywords: factors; pulmonary response to inhaled particulate matter - physiochemical properties of particles; particle characteristics; influencing bioactivity - diameter; deposition site and lung burden; pulmonary response to inhaled particles - influenced by deposition fraction and deposition site
Publication Date
20110101
Document Type
Book or book chapter
Editors
Kulkarni-P; Baron-PA; Willeke-K
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISBN No.
9780470387412
NIOSH Division
HELD
Source Name
Aerosol Measurement: Principles, Techniques, and Applications, Third Edition
State
WV
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