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The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis.

Authors
Huttemann-M; Pecina-P; Rainbolt-M; Sanderson-TH; Kagan-VE; Samavati-L; Doan-JW; Lee-I
Source
Mitochondrion 2011 May; 11(3):369-381
NIOSHTIC No.
20039193
Abstract
Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy conditions, produces ROS with the co-factor p66(Shc), and oxidizes cardiolipin during apoptosis. The recent finding that Cytc is phosphorylated in vivo underpins a model for the pivotal role of Cytc regulation in making life and death decisions. An apoptotic sequence of events is proposed involving changes in Cytc phosphorylation, increased ROS via increased mitochondrial membrane potentials or the p66(Shc) pathway, and oxidation of cardiolipin by Cytc followed by its release from the mitochondria. Cytc regulation in respiration and cell death is discussed in a human disease context including neurodegenerative and cardiovascular diseases, cancer, and sepsis.
Keywords
Cell-biology; Cell-cultures; Cell-damage; Cell-function; Cancer; Cardiovascular-disease; Cardiovascular-system-disease; Mammalian-cells; Author Keywords: Aging; Apoptosis; Cardiolipin; Cell signaling; Cytochrome c; Oxidative phosphorylation; Reactive oxygen species
Contact
Petr Pecina, Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Vídenská 1083, Prague, Czech Republic
CODEN
MITOCN
CAS No.
9007-43-6
Publication Date
20110501
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282
Issue of Publication
3
ISSN
1567-7249
Source Name
Mitochondrion
State
MI; PA
Performing Organization
University of Pittsburgh at Pittsburgh
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