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Haptenation: chemical reactivity and protein binding.

Authors
Chipinda-I; Hettick-JM; Siegel-PD
Source
J Allergy 2011 Jan; 2011:839682
NIOSHTIC No.
20039185
Abstract
Low molecular weight chemical (LMW) allergens are commonly referred to as haptens. Haptens must complex with proteins to be recognized by the immune system. The majority of occupationally related haptens are reactive, electrophilic chemicals, or are metabolized to reactive metabolites that form covalent bonds with nucleophilic centers on proteins. Nonelectrophilic protein binding may occur through disulfide exchange, coordinate covalent binding onto metal ions on metalloproteins or of metal allergens, themselves, to the major histocompatibility complex. Recent chemical reactivity kinetic studies suggest that the rate of protein binding is a major determinant of allergenic potency; however, electrophilic strength does not seem to predict the ability of a hapten to skew the response between Th1 and Th2. Modern proteomic mass spectrometry methods that allow detailed delineation of potential differences in protein binding sites may be valuable in predicting if a chemical will stimulate an immediate or delayed hypersensitivity. Chemical aspects related to both reactivity and protein-specific binding are discussed.
Keywords
Allergens; Allergic-reactions; Allergies; Chemical-binding; Chemical-hypersensitivity; Immune-reaction; Immune-system-disorders; Metabolic-activation; Metabolic-disorders; Metabolic-study; Metabolites; Quantitative-analysis; Respiratory-hypersensitivity; Respiratory-irritants; Spectrographic-analysis
Contact
Paul D. Siegel, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS L-2040, 1095 Willowdale Road, Morgantown, WV 26505, USA
Publication Date
20110101
Document Type
Journal Article
Email Address
psiegel@cdc.gov
Editors
Sussman-GL
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISSN
1687-9783
NIOSH Division
HELD
Priority Area
Services
Source Name
Journal of Allergy
State
WV
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