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Employment and work schedule are related to telomere length in women.

Authors
Parks-CG; DeRoo-LA; Miller-DB; McCanlies-EC; Cawthon-RM; Sandler-DP
Source
Occup Environ Med 2011 Aug; 68(8):582-589
NIOSHTIC No.
20039179
Abstract
Objectives: To examine the association of employment and work schedule with shorter DNA telomeres, a marker of cellular ageing and disease risk factor, and consider whether differences were related to health, behaviours and sociodemographic factors, or varied by stress levels or menopausal status. Methods: This cross-sectional analysis of 608 women aged 35-74 in the Sister Study examined determinants of relative telomere length (rTL) measured by quantitative PCR in leucocyte DNA. Age-adjusted regression models estimated base pair (bp) rTL differences for current and lifetime schedule characteristics (ie, part-time, full-time or overtime hours; multiple jobs; irregular hours; shiftwork; work at night). Covariates included race, smoking, perceived stress, sleep, physical activity, health and menopausal status, education, marital status, live births, children under 18, measured body mass index and urinary stress hormones. Results: Compared with non-employed women with moderate or substantial past work histories (n=190), those currently working full-time (n=247; median 40 h/week) had a shorter rTL, an age-adjusted difference of -329 bp (95% CI -110 to -548). Longer-duration full-time work was also associated with shorter rTL (age-adjusted difference of -472 bp, 95% CI -786 to -158 for 20+ vs 1-5 years). Findings were not explained by health and demographic covariates. However, rTL differences for working at least full-time were greater in women with higher stress and epinephrine levels. Conclusions: Current and long-term full-time work were associated with shorter rTL, with differences of similar magnitude to smoking and history of heart disease or diabetes. Longitudinal data with specific stress measures are needed to further evaluate the impact of work schedule on rTL.
Keywords
Age-factors; Behavior-patterns; Biomarkers; Cellular-reactions; Circadian-rhythms; Demographic-characteristics; Mathematical-models; Physical-exercise; Risk-factors; Shift-workers; Sleep-deprivation; Sociological-factors; Women; Worker-health; Workplace-studies
Contact
Christine G Parks, Epidemiology Branch, A3-05, NIEHS, PO Box 12233, Research Triangle Park, NC 27599, USA
CODEN
OEMEEM
Publication Date
20110801
Document Type
Journal Article
Email Address
parks1@mail.nih.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
1351-0711
NIOSH Division
HELD
Source Name
Occupational and Environmental Medicine
State
WV; NC; UT
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