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Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells.

Authors
Tessier-DM; Pascal-LE
Source
Toxicol Lett 2006 Dec; 167(2):114-121
NIOSHTIC No.
20039117
Abstract
Epidemiological studies indicate that workers who perform welding operations are at increased risk for bronchitis, siderosis, occupational asthma and lung cancer due to fume exposure. Welding fumes are a complex chemical mixture, and the metal composition is hypothesized to be an etiological factor in respiratory disease due to this exposure. In the present study, human lung epithelial cells in vitro responded to hexavalent chromium, manganese and nickel over a concentration range of 0.2-200 microM with a significant increase in intracellular phosphoprotein (a measure of stress response pathway activation). The mitogen-activated protein kinases ERK1/2, SAPK/JNK and p38 were activated via phosphorylation following 1-h exposures. Hexavalent chromium up-regulated p-38 phosphorylation 23-fold and SAPK/JNK phosphorylation 17-fold, with a comparatively modest 4-fold increase in ERK1/2 phosphorylation. Manganese caused a two- to four-fold increase in SAPK/JNK and ERK 1/2 phosphorylation, with no observed effects on p38 kinase. Nickel caused increased (two-fold) phosphorylation of ERK 1/2 only, and was not cytotoxic over the tested concentration range. The observed effects of welding fume metals on cellular signaling in lung epithelium demonstrate a potentially significant interplay between stress-response signaling (p38 and SAPK/JNK) and anti-apototic signaling (ERK 1/2) that is dependant on the specific metal or combination of metals involved.
Keywords
Welding; Welders; Welding-industry; Nickel-compounds; Humans; Epidemiology; Chromium-compounds; Toxic-effects; Cell-growth; Cell-function; Cell-cultures; Cancer; Lung-cancer; Lung-disease; Lung-disorders; Respiratory-system-disorders; Pulmonary-system-disorders; Author Keywords: Welding fumes; MAP kinases; Chromium; Manganese; Nickel
CODEN
TOLED5
CAS No.
18540-29-9; 7439-96-5; 7440-02-0
Publication Date
20061201
Document Type
Journal Article
Email Address
dmt@uic.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-CCT-510424; Grant-Number-T42-OH-008672
Issue of Publication
2
ISSN
0378-4274
Source Name
Toxicology Letters
State
IL
Performing Organization
University of Illinois at Chicago, School of Public Health
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