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Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter.

Authors
Erdely-A; Salmen-Muniz-R; Liston-A; Hulderman-T; Zeidler-Erdely-PC; Antonini-JM; Simeonova-PP
Source
Toxicology 2011 Sep; 7(1-3):153-159
NIOSHTIC No.
20039071
Abstract
Welding results in a unique and complex occupational exposure. Recent epidemiological studies have shown an increased risk of cardiovascular disease following welding fume exposure. In this study, we compared the induction of pulmonary and systemic inflammation following exposure to multiple types of welding fumes. Mice were exposed to 340mcg of manual metal arc stainless steel (MMA-SS), gas metal arc-SS (GMA-SS) or GMA-mild steel (GMA-MS) by pharyngeal aspiration. Mice were sacrificed at 4 and 24h post-exposure to evaluate various parameters of pulmonary and systemic inflammation. Alterations in pulmonary gene expression by a custom designed TaqMan array showed minimal differences between the fumes at 4h. Conversely at 24h, gene expression changes were further increased by SS but not GMA-MS exposure. These findings were associated with the surrogate marker of systemic inflammation, liver acute phase gene induction. Interestingly, stress response genes in cardiovascular tissues were only increased following MMA-SS exposure. These effects were related to the initial level of pulmonary cytotoxicity, as measured by lactate dehydrogenase activity, which was greatest following MMA-SS exposure. In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses.
Keywords
Welding; Biomarkers; Biological-effects; Respiratory-system-disorders; Pulmonary-function; Pulmonary-system-disorders; Lung-disorders; Lung-function; Particulates; Fumes; Metal-fumes; Immune-reaction; Laboratory-animals; Animal-studies; Animals; Stainless-steel; Gene-mutation; Genes; Cell-alteration; Dose-response; Quantitative-analysis; Cytotoxic-effects; Cytotoxicity; Cardiopulmonary-function; Cardiovascular-function; Proteins; Author Keywords: Systemic inflammation; Cardiovascular; Bronchoalveolar lavage; Gene expression; Serum proteins; Aorta
Contact
Aaron Erdely, NIOSH/HELD/PPRB, 1095 Willowdale Road, MS-2015, Morgantown, WV 26505-2888, USA
CODEN
TXCYAC
Publication Date
20110905
Document Type
Journal Article
Email Address
efi4@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISSN
0300-483X
NIOSH Division
HELD
Source Name
Toxicology
State
WV
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