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Efficacy of predictive modeling as a scientific criterion in dermal hazard identification for assignment of skin notations.

Authors
Chen-C-P; Ahlers-HW; Dotson-GS; Lin-Y-C; Chang-W-C; Maier-A; Gadagbui-B
Source
Regul Toxicol Pharmacol 2011 Oct; 61(1):63-72
NIOSHTIC No.
20039047
Abstract
Skin notations (SNs) represent a hazard characterization tool for alerting workers of health hazards associated with dermal contact with chemicals. This study evaluated the efficacy of a predictive model utilized by the National Institute for Occupational Safety and Health to identify dermal hazards based on potential of systemic absorption compared to hazard assignments based on dermal lethal dose 50% or logarithm of octanol-water partition coefficient. A total of 480 chemicals assigned an SN from at least one of seven institutes were selected and partitioned into seven hazard categories by frequency of SN assignment to provide a basis of evaluation for the predictivity of the examined criteria. We find that all three properties serve as a qualitative indicator in support of a dichotomous decision on dermal hazard; the predictive modeling was identified from a multiple regression analysis as the most significant indicator. The model generated estimates that corresponded to anticipated hazard potentials, suggesting a role of the model to further serve as a hazard-ranking tool. The hazard-ranking capability of the model was consistent with the scheme of acute toxicity classification in the Globally Harmonized System of Classification and Labeling of Chemicals.
Keywords
Biohazards; Biological-effects; Biological-factors; Chemical-hypersensitivity; Chemical-properties; Exposure-assessment; Exposure-levels; Immune-reaction; Immunology; Mathematical-models; Occupational-dermatitis; Qualitative-analysis; Risk-analysis; Risk-factors; Skin-absorption; Skin-disorders; Skin-exposure; Skin-infections; Skin-irritants; Skin-sensitivity; Toxic-effects; Toxicology; Toxins; Dermal-exposure; Dermal-absorption; Author Keywords: Occupational skin exposure; Skin notation; Hazard characterization; Predictive modeling; Dermal lethal dose 50%; Octanol-water partition coefficient; Globally Harmonized System of Classification and Labeling of Chemicals; Hazard ranking
Contact
Chen-Peng Chen, China Medical University, Department of Occupational Safety and Health, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan
CODEN
RTOPDW
Publication Date
20111001
Document Type
Journal Article
Email Address
chencp@mail.cmu.edu.tw
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0273-2300
NIOSH Division
NPPTL; EID
Source Name
Regulatory Toxicology and Pharmacology
State
PA; OH
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