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Mortality patterns among workers in a US pharmaceutical production plant.

Authors
Marsh-GM; Youk-AO; Esmen-NA; Buchanich-JM
Source
Ann Epidemiol 2005 Feb; 15(2):112-122
NIOSHTIC No.
20039041
Abstract
PURPOSE: To examine mortality among workers in a pharmaceutical production plant and to address community concerns about 1980 to 1990 increases in local county cancer mortality rates. METHODS: Subjects were 1999 workers with some full-time employment during the period between 1970 and 1996. We identified deaths through the year 2000 and reconstructed exposures to nine chemical agents with available exposure measurements. Data analyses included standardized mortality ratios (SMRs) and time trends in local cancer mortality rates. RESULTS: We observed deficits in deaths from all causes combined, all cancers combined, and most cause of death categories examined. Male workers with potential plant exposure had excesses in deaths from all lymphatic-hematopoietic tissue cancers (LHTC), in particular non-Hodgkin's lymphoma (NHL), and respiratory system cancers (RSC) that were larger among long-term workers, but the pattern of findings suggested the excesses were probably not related to occupational factors at the plant. The increase in local county cancer mortality rates was simply the upward cycle of a periodic trend that peaked in 1990 and returned to 1980 levels in 2000. CONCLUSIONS: With the possible exceptions of LHTC, in particular NHL, and RSC, this study provided no evidence of elevated total or cause-specific cohort mortality risks. It does not appear that plant factors played a role in the 1980 to 1990 increases in local county cancer mortality rates.
Keywords
Pharmaceuticals; Pharmaceutical-industry; Cancer; Cancer-rates; Mortality-rates; Mortality-data; Workers; Work-environment; Worker-health; Exposure-limits; Author Keywords: Pharmaceutical Production; Cohort Study; Mortality; Lymphatic and Hematopoietic Tissue Cancers; Non-Hodgkin's Lymphoma; Respiratory System Cancer
Contact
Gary M. Marsh, Ph.D., Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
CODEN
ANNPE3
Publication Date
20050201
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008672
Issue of Publication
2
ISSN
1047-2797
Source Name
Annals of Epidemiology
State
IL; PA
Performing Organization
University of Illinois-Chicago
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