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Cytotoxicity of chromium and manganese to lung epithelial cells in vitro.

Authors
Pascal-LE; Tessier-DM
Source
Toxicol Lett 2004 Mar; 147(2):143-151
NIOSHTIC No.
20039021
Abstract
Chromium, nickel and manganese are the predominant metals in welding fumes and are associated through epidemiological studies with an increased risk for developing occupational asthma due to welding activities. Here, we show that chromium(VI) and manganese, but not nickel, are cytotoxic to normal human lung epithelial cells in vitro (SAEC and BEAS-2B), at concentration ranges of 0.2-200 microM. The toxic effect was associated with increased levels of intracellular phosphoprotein and subsequent release of inflammatory cytokines IL-6 and IL-8, while no release of TNF-alpha was observed. Changes in intracellular phosphoprotein levels occurred at concentrations below the cytotoxic effect. IL-6 and IL-8 production increased up to 4.4-fold relative to controls. IL-6 and IL-8 are released from lung epithelium to recruit cells of the immune system to sites of tissue damage. Therefore, the observed effects of chromium(VI) and manganese in lung epithelial cells demonstrate a mechanism through which the toxicity of these metals to epithelial cells can result in recruitment of cells of the immune system.
Keywords
Chromium-compounds; Nickel-compounds; Manganese-compounds; Metal-compounds; Welding; Fumes; Lung; Lung-cells; Pulmonary-function; Pulmonary-disorders; Respiratory-system-disorders; Author Keywords: Lung epithelium; Cytotoxicity; Protein phosphorylation; IL-6; IL-8; Metals
Contact
Daniel M. Tessier; Division of Environmental & Occupational Health Sciences, School of Public Health, University of Illinois Chicago, SPH/EOHS/MC922, 2121 West Taylor Street, Chicago, IL 60612
CODEN
TOLED5
CAS No.
7440-02-0; 7439-96-5; 18540-29-9
Publication Date
20040301
Document Type
Journal Article
Email Address
dmt@uic.edu
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008672
Issue of Publication
2
ISSN
0378-4274
Source Name
Toxicology Letters
State
IL
Performing Organization
University of Illinois-Chicago
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