Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The evolution of skin notations for occupational risk assessment: a new NIOSH strategy.

Authors
Dotson-GS; Chen-C-P; Gadagbui-B; Maier-A; Ahlers-HW; Lentz-TJ
Source
Regul Toxicol Pharmacol 2011 Oct; 61(1):53-62
NIOSHTIC No.
20039006
Abstract
This article presents an overview of a strategy for assignment of hazard-specific skin notations (SK), developed by the National Institute for Occupational Safety and Health (NIOSH). This health hazard characterization strategy relies on multiple SKs capable of delineating systemic (SYS), direct (DIR), and immune-mediated (SEN) adverse effects caused by dermal exposures to chemicals. One advantage of the NIOSH strategy is the ability to combine SKs when it is determined that a chemical may cause multi ple adverse effects following dermal contact (e.g., SK: SYS-DIR-SEN). Assignment of the SKs is based on a weight-of-evidence (WOE) approach, which refers to the critical examination of all available data from diverse lines of evidence and the derivation of a scientific interpretation based on the collective body of data including its relevance, quality, and reported results. Numeric cutoff values, based on indices of toxic potency, serve as guidelines to aid in consistently determining a chemical's relative toxicity and hazard potential. The NIOSH strategy documents the scientific rationale for determination of the hazard potential of a chemical and the subsequent assignment of SKs. A case study of acrylamide is presented as an application of the NIOSH strategy.
Keywords
Biohazards; Biological-effects; Biological-factors; Chemical-hypersensitivity; Exposure-assessment; Immune-reaction; Immunology; Risk-analysis; Risk-factors; Skin-absorption; Skin-disorders; Skin-exposure; Skin-infections; Skin-irritants; Skin-sensitivity; Toxic-effects; Toxic-materials; Toxicology; Author Keywords: Skin notations; Skin; Chemicals; Occupational; Hazard characterization; Risk assessment; Dermal-exposure; Dermal-absorption
CODEN
RTOPDW
Publication Date
20111001
Document Type
Journal Article
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0273-2300
NIOSH Division
NPPTL; EID
Source Name
Regulatory Toxicology and Pharmacology
State
OH; PA
TOP