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Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.

Authors
Wang-L; Luanpitpong-S; Castranova-V; Tse-W; Lu-Y; Pongrakhananon-V; Rojanasakul-Y
Source
Nano Lett 2011 Jul; 11(7):2796-2803
NIOSHTIC No.
20038986
Abstract
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
Keywords
Nanotechnology; Nanotubes; Carcinogenicity; Chronic-exposure; Malignancy; Lung; Lung-cells; Lung-disorders; Cell-alteration; Cell-damage; Cellular-reactions; Tumorigenesis; Laboratory-animals
Contact
Yon Rojanasakul, Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, 26505, USA
CODEN
NALEFD
CAS No.
7440-44-0
Publication Date
20110713
Document Type
Journal Article
Email Address
yrojan@hsc.wvu.edu
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1530-6984
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Nano Letters
State
WV
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