Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
Wang-L; Luanpitpong-S; Castranova-V; Tse-W; Lu-Y; Pongrakhananon-V; Rojanasakul-Y
Nano Lett 2011 Jul; 11(7):2796-2803
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
Nanotechnology; Nanotubes; Carcinogenicity; Chronic-exposure; Malignancy; Lung; Lung-cells; Lung-disorders; Cell-alteration; Cell-damage; Cellular-reactions; Tumorigenesis; Laboratory-animals
Yon Rojanasakul, Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, 26505, USA