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Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.

Authors
Tkach-AV; Shurin-GV; Shurin-MR; Kisin-ER; Murray-AR; Young-SH; Star-A; Fadeel-B; Kagan-VE; Shvedova-AA
Source
ACS Nano 2011 Jun; 5(7):5755-5762
NIOSHTIC No.
20038985
Abstract
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naive T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
Keywords
Nanotechnology; Nanotubes; Nanoparticles; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Lung-cells; Lung-disorders; Lung-tissue; Cell-damage; Cellular-function; Cellular-reactions; In-vivo-study; Immune-reaction; Immune-system; In-vitro-study; Cell-alteration; Cytology; Author Keywords: dendritic cells; nanoparticles; immune system; immunosuppression; nanotubes
Contact
Alexey V. Tkach, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
ANCAC3
CAS No.
7440-44-0
Publication Date
20110615
Document Type
Journal Article
Email Address
ats1@cdc.gov
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008282
Issue of Publication
7
ISSN
1936-0851
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
ACS Nano
State
WV; PA
Performing Organization
University of Pittsburgh at Pittsburgh
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