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Thyroxine and free thyroxine levels in workers occupationally exposed to inorganic lead.

Authors
Bledsoe-ML; Pinkerton-LE; Silver-S; Deddens-JA; Biagini-RE
Source
Environ Health Insights 2011 Jun; 5:55-61
NIOSHTIC No.
20038966
Abstract
Background: The effects of lead exposure on thyroid function are unclear. Methods: Serum thyroxine (T4) was evaluated among 137 lead-exposed workers and 83 non-exposed workers. Free thyroxine (FT4) was evaluated among a subset of these workers. Exposure metrics included blood lead level (BLL), which reflects recent exposure, zinc protoporphyrin (ZPP), a marker of intermediate-duration lead exposure, exposure duration, and estimated cumulative exposure. Multiple linear regression results were adjusted for age, race, and current smoking status. Results: Mean BLLs were 38.9 g/dL in lead exposed workers and 2.1 g/dL in non-exposed workers. The adjusted mean T4 and FT4 concentrations among exposed and non-exposed workers were similar. While T4 was not significantly related to any of the exposure metrics, FT4 was inversely related to the logged values of both exposure duration and cumulative exposure, but not to ZPP or BLL. Conclusions: The findings suggest that FT4 levels may be related to long-term lead exposure.
Keywords
Age-factors; Exposure-assessment; Exposure-levels; Mathematical-models; Occupational-exposure; Occupational-health; Racial-factors; Smoking; Time-weighted-average-exposure; Work-environment; Worker-health; Workplace-studies; Epidemiology; Statistical-analysis; Demographic-characteristics; Heavy-metals; Author Keywords: thyroxine; free thyroxine; lead; occupational exposure
Contact
Michael L. Bledsoe, Occupational Medicine Services, 78th Aerospace Medicine Squadron, 78th Medical Group, United States Air Force, Robins Air Force Base, GA
CODEN
EHINA4
CAS No.
7439-92-1
Publication Date
20110614
Document Type
Journal Article
Email Address
michael.bledsoe@us.af.mil
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISSN
1178-6302
NIOSH Division
DSHEFS; DART
Priority Area
Manufacturing
Source Name
Environmental Health Insights
State
OH
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