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Observations concerning alveolar dust clearance.

Authors
Ferin-J
Source
Ann NY Acad Sci 1972 Dec; 200(1):66-72
NIOSHTIC No.
20038841
Abstract
Experiments with rats exposed to titanium-dioxide (7440326) dust reveal that the onset of alveolar clearance is immediate in terms of minutes, overlapping in time with the rapid clearance of particles from the tracheobronchial tree. Two days after the onset of exposure the number of alveolar macrophages is significantly increased. In 88 days (half time), 50 percent of the initial lung burden is cleared. Multiple exposures may change the clearance rate. Clearance efficiency may improve by experimental means. Lung clearance of titanium-dioxide in animals subjected to preliminary exposure to sulfur-dioxide (7446095) is significantly depressed.
Keywords
NIOSH-Grant; Respiratory-functions; Lung-clearance; Respiratory-mechanics; Inorganic-gases; Toxic-gases; Dust-inhalation; Lung-dust-burden
CODEN
ANYAA9
CAS No.
7440-32-6; 7446-09-5
Publication Date
19721229
Document Type
Journal Article
Funding Amount
292984
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00334
Issue of Publication
1
ISSN
0077-8923
Source Name
Annals of the New York Academy of Sciences
State
NY
Performing Organization
University of Rochester, Rochester, New York
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