Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

NIOSH skin notation (SK) profile: nitroglycerin [CAS No. 55-63-8].

Authors
Dotson-GS
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2011-147, 2011 Apr; :1-13
NIOSHTIC No.
20038794
Abstract
This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with nitroglycerin and (2) the rationale behind the hazard-specific skin notation (SK) assignment for nitroglycerin. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to nitroglycerin. A literature search was conducted through July 2010 to identify information on nitroglycerin, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to nitroglycerin. Nitroglycerin is potentially capable of causing multiple adverse health effects following skin contact. A critical review of available data has resulted in the following SK assignment for nitroglycerin: SK: SYS (FATAL)-DIR (IRR)-SEN. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for nitroglycerin.
Keywords
Skin; Skin-absorption; Skin-exposure; Skin-irritants; Chemical-analysis; Chemical-composition; Chemical-kinetics; Chemical-properties; Chemical-reactions; Chemical-structure; Health-hazards; Biological-effects; Dermatology; Exposure-assessment; Dose-response; Toxic-dose; Toxic-effects; Carcinogenicity; Kinetics; Sensitization; Reproductive-effects; Immunologic-disorders; Developmental-disorders; Nitrates; Esters; Dermal-exposure; Dermal-absorption
CAS No.
55-63-0
Publication Date
20110401
Document Type
Numbered Publication
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
(NIOSH) 2011-147
NIOSH Division
EID; NPPTL; OD
Source Name
National Institute for Occupational Safety and Health
State
OH; PA; CO
TOP